Fig. 1
Tumor growth. The growth of MDA-MB-231 and MDA-MB-468 xenograft tumors (a-c) in WT and α11-KO mice. A total of 5 × 105 MDA-MB-231 and 1.5 × 106 MDA-MB-468 cells were injected into the mammary fat pad, and for MDA-MB-231, also subcutaneously (s.c.) on the back. All MDA-MB-231 injected mice were sacrificed at day 57 post injection. The MDA-MB-468 injected mice were sacrificed at different time points starting with n = 20 WT and n = 16 α11-KO. Mean ± SEM. ** p < 0.01. Immunofluorescence staining of integrin α11 (red), cytokeratin AE1/AE3 (green) and DAPI (blue) in MDA-MB-231 and MDA-MB-468 xenograft tumors (d) in WT and α11-KO mice. Scale bars indicate 50 μm