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Table 1 Correlation between IHC gradings of 5 biomarkers across variables: Intra-class correlation coefficient (ICC) for IHC gradings of all 5 CAB biomarkers tested for inter-observer, intra-observer, inter-operator, inter-run and intra-run variability

From: Analytical validation of CanAssist-Breast: an immunohistochemistry based prognostic test for hormone receptor positive breast cancer patients

Variables

Percentage of cells stained

Intensity of staining

 

CD44

ABCC4

ABCC11

N-Cadherin

Pan-Cadherin

Pan-Cadherin

Inter-observer

0.98

0.84

0.83

0.79

0.75

0.84

Intra-observer

0.96

0.91

0.91

0.92

0.92

0.81

Inter-operator

0.98

0.97

0.97

0.86

0.90

0.94

Inter-run

0.97

0.93

0.97

0.97

0.95

0.93

Intra-run/Intra-operator

0.99

0.99

0.99

0.99

0.98

0.97

  1. Place holder for Table 1 Can be placed in Inter-observer (pathologist) variability section in “Results” at line no. 221