Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohort

Table 2 Associations between the genetic polymorphism and neutropenia for docetaxel treatment in the 69 NSCLC patients

SNP	Genotype	n	Grade 3 or 4 neutropenia, %	p-value	febrile neutropenia, n	p-value	adjusted odds ratio^a	p-value
ABCC10 rs2125739	TT	54	87.0%	0.028	11	0.105		0.013
ABCC10 rs2125739	TC	15	60.0%		0		0.16 (0.03–0.68)
ABCB1 3435C > T	CC	25	88.0%	0.349	4	1.000		0.345
ABCB1 3435C > T	CT + TT	44	77.3%		7		0.50 (0.12–2.09)
ABCB1 2677G > T/A	GG	10	100.0%	0.189	3	0.192		–
ABCB1 2677G > T/A	GT + TT + GA + AA+TA	59	78.0%		8		–
ABCB1 1236C > T	CC	12	75.0%	0.685	0	0.191		0.546
ABCB1 1236C > T	CT + TT	57	82.5%		11		1.60 (0.35–7.31)
ABCC2 rs12762549	CC	12	100.0%	0.104	1	0.674		–
ABCC2 rs12762549	CG + GG	57	77.2%		10		–
SLCO1B3 rs11045585	GG	54	77.8%	0.270	9	1.000		0.185
SLCO1B3 rs11045585	GA	15	93.3%		2		4.31 (0.50–37.3)

^aodds ratio of frequency of grade 3/4 neutropenia adjusted by age and sex in a logistic regression analysis
SNP, single nucleotide polymorphism

ISSN: 1471-2407