Table 2 The risk of death in ICC patients according to the expression of Beclin-1, ARID1A, IDH1 and CA9
IHC Intensity | Follow-up (Month) | Number of Death | Rate, n/1000 person-month | Crude HR (95% CI) |
|---|---|---|---|---|
Beclin-1 | ||||
 0 | 688.41 | 7 | 10.17 | 1.0 |
 1 | 1036.01 | 18 | 17.37 | 1.60 (0.67–3.83) |
 2 | 811.01 | 32 | 39.46 | 3.02 (1.32–6.91) |
 3 | 529.00 | 18 | 34.03 | 2.95 (1.22–7.12) |
 Negative | 688.41 | 7 | 10.17 | 1.0 |
 Positive | 2376.02 | 68 | 28.62 | 2.39 (1.09–5.24) |
ARID1A | ||||
 0 | 1225.53 | 20 | 16.32 | 1.0 |
 1 | 984.01 | 32 | 32.52 | 1.71 (0.98–3.00) |
 2 | 712.29 | 19 | 26.67 | 1.49 (0.79–2.80) |
 3 | 142.60 | 4 | 28.05 | 1.29 (0.44–3.78) |
 Negative | 1225.53 | 20 | 16.32 | 1.0 |
 Positive | 1838.90 | 55 | 29.91 | 1.59 (0.95–2.66) |
IDH1 | ||||
 0 | 287.39 | 5 | 17.40 | 1.0 |
 1 | 627.57 | 17 | 27.09 | 1.10 (0.40–2.99) |
 2 | 1423.95 | 32 | 22.47 | 1.001 (0.39–2.58) |
 3 | 725.52 | 21 | 28.94 | 1.09 (0.41–2.92) |
 Negative | 287.39 | 5 | 17.40 | 1.0 |
 Positive | 2777.04 | 70 | 25.21 | 1.05 (0.42–2.61) |
CA9 | ||||
 0 | 654.60 | 10 | 15.28 | 1.0 |
 1 | 641.92 | 24 | 37.39 | 1.53 (0.73–3.22) |
 2 | 985.60 | 25 | 25.37 | 1.08 (0.52–2.25) |
 3 | 782.31 | 16 | 20.45 | 0.96 (0.44–2.12) |
 Negative | 654.60 | 10 | 15.28 | 1.0 |
 Positive | 2409.83 | 65 | 26.97 | 1.17 (0.60–2.27) |