Skip to main content

Advertisement

Table 1 Derivation of cost data and associated cost calculations

From: Cost burden associated with advanced non-small cell lung cancer in Europe and influence of disease stage

Cost Definition
Direct out-of-pocket costsa
 Wage losses (A)b The reduction in the number of hours worked per weekc multiplied by the average hourly earnings in each countryd. Annualized by multiplying by 48e.
 Non-medical GP/hospital visit expenses (B) The reported number of visits to the GP/hospital in the last 3 months was annualized by multiplying by 4. This product was then multiplied by the sum of transportation costs to GP/hospital and other out-of-pocket expenses when visiting the GP/hospital.
 Secondary NSCLC-related treatment costs (C)f The amount paid in the last week for treatments for conditions linked to NSCLC (e.g., pain or other symptom relief). Annualized by multiplying by 52.
 Other non-medical monetary burden costs (D) Cost of additional non-medical resources required per week as a result of NSCLC (e.g., child care, housekeeper/cleaner, gardener, taxi/transportation). Annualized by multiplying by 52.
Indirect out-of-pocket costsg
 Productivity losses (E)h Sum of cost of absenteeism (hours of work missed in the last weeki due to NSCLC-related health problem multiplied by the average hourly earnings per countryd) and cost of presenteeism (percentage impaired while workingi multiplied by the number of hours worked in the last 7 days, multiplied by the average hourly earnings per countryd). Annualized by multiplying by 48e.
Government financial support
 Government financial support (F) Financial support received by the patient or caregiver from the government per week (e.g., disability allowance, home care benefits, sick leave remuneration). Annualized by multiplying by 52.
Cost calculation Formula
 Direct out-of-pocket expenses (unadjusted) A + B + C + D
 Direct out-of-pocket expenses (adjusted)j (A + B + C + D) - F
 Total direct and indirect out-of-pocket costs (unadjusted)k A + B + C + D + E
 Total direct and indirect out-of-pocket costs (adjusted)j (A + B + C + D + E) - F
  1. NSCLC non-small cell lung cancer
  2. aNSCLC costs directly borne by the patient or caregiver
  3. bAnnual wage loss was assumed to be €0.00 for patients/caregivers who were not in employment prior to NSCLC diagnosis/caring for the patient with NSCLC
  4. cIf no change in employment status, this was assumed to be 0 h; if changed to unemployed, assumed average hours per working week in each country, based on Eurostat 2015 estimates – France: 37.2 h; Germany: 35.2 h; Italy: 37.0 h
  5. dBased on Eurostat 2014 estimates – France: €17.40; Germany: €17.78; Italy: €15.54
  6. eAssumes 48 working weeks per year
  7. fCosts for primary NSCLC treatment (e.g., chemotherapy) are not included; only includes costs related to secondary medications required to address NSCLC-related symptoms
  8. gNSCLC costs not borne by patients or caregivers (i.e., cost to employers)
  9. hProductivity losses for patients and caregivers not in current employment were conservatively assumed to be €0.00
  10. iMeasured using the Work Productivity and Activity Impairment Questionnaire: General Health [16]
  11. jAdjusted for financial support provided by the respective governments
  12. kRepresents the sum of all cost components, but does not account for government financial support subsidizing patient or caregiver direct costs