Direct outofpocket costs^{a}

Wage losses (A)^{b}

The reduction in the number of hours worked per week^{c} multiplied by the average hourly earnings in each country^{d}. Annualized by multiplying by 48^{e}.

Nonmedical GP/hospital visit expenses (B)

The reported number of visits to the GP/hospital in the last 3 months was annualized by multiplying by 4. This product was then multiplied by the sum of transportation costs to GP/hospital and other outofpocket expenses when visiting the GP/hospital.

Secondary NSCLCrelated treatment costs (C)^{f}

The amount paid in the last week for treatments for conditions linked to NSCLC (e.g., pain or other symptom relief). Annualized by multiplying by 52.

Other nonmedical monetary burden costs (D)

Cost of additional nonmedical resources required per week as a result of NSCLC (e.g., child care, housekeeper/cleaner, gardener, taxi/transportation). Annualized by multiplying by 52.

Indirect outofpocket costs^{g}

Productivity losses (E)^{h}

Sum of cost of absenteeism (hours of work missed in the last week^{i} due to NSCLCrelated health problem multiplied by the average hourly earnings per country^{d}) and cost of presenteeism (percentage impaired while working^{i} multiplied by the number of hours worked in the last 7 days, multiplied by the average hourly earnings per country^{d}). Annualized by multiplying by 48^{e}.

Government financial support

Government financial support (F)

Financial support received by the patient or caregiver from the government per week (e.g., disability allowance, home care benefits, sick leave remuneration). Annualized by multiplying by 52.

Cost calculation

Formula

Direct outofpocket expenses (unadjusted)

A + B + C + D

Direct outofpocket expenses (adjusted)^{j}

(A + B + C + D)  F

Total direct and indirect outofpocket costs (unadjusted)^{k}

A + B + C + D + E

Total direct and indirect outofpocket costs (adjusted)^{j}

(A + B + C + D + E)  F
