Fig. 7

PPARγ activation suppresses signaling transduction that controls cell cycle and apoptosis in Akt pathway. (a) Immunofluorescence staining of PPARγ and phospho-FoxO1 (Ser256) in 5637 cells. Cells seeded on cover slides were treated with solvent (0.1%DMSO) or rosiglitazone (20 μM) for 12 h. (b) Western blotting of PPARγ and downstream molecules in Akt pathway. 5637 cells were treated with rosiglitazone and T0070907 (10, 20 μM) for 72 h. (c) Schematic illustration of the suppressive effect of PPARγ activation against bladder cancer