Table 1 Proteogenomics profiling of the expression of complement and complement-related components in patients with lung cancer
Type | Gene symbol | mRNA level | Protein level | Protein level |
|---|---|---|---|---|
in tissue | in tissue | in serum | ||
Activators | ||||
C1s | − 2.20 ± 0.76 | − 2.15 ± 0.88 | 1.76 ± 0.77 | |
C1r | − 2.57 ± 1.02 | − 4.4 | 2.10 ± 0.14 | |
C1QA | − 1.83 ± 0.53 | − 1.84 ± 0.23 | 2.1 | |
Early | C1QB | − 1.69 ± 0.64 | − 3.01 ± 0.79 | 0.87 |
C1QC | − 1.65 ± 0.51 | − 2.06 ± 2.11 | NA | |
C2 | − 1.40 ± 0.75 | − 1.17 | 1.40 ± 0.3 | |
C4/C4a, b, d | − 2.20 ± 0.18 | − 1.94 ± 0.1 | 1.33 ± 0.36 | |
●MASP1 | − 1.5 | NA | NA | |
CFD | −2.38 ± 0.72 | NA | NA | |
Middle | CFP | −2.29 ± 0.86 | NA | NA |
CFB | 1.52 ± 0.16 | −2.23 ± 1.26 | 3.17 ± 1.37 | |
C3/C3c, b | − 3.65 ± 182 | −3.09 ± 1.17 | 2.19 ± 1.25 | |
C5 | − 1.59 ± 0.43 | − 1.31 ± 0.3 | 2.00 ± 1.73 | |
C6 | −3.74 ± 2.58 | − 1.50 ± 0.15 | 2.78 ± 2.23 | |
C7 | −2.30 ± 0.99 | −2.05 ± 0.65 | 2.85 ± 0.95 | |
Late | C8A | −0.2 | − 1.97 ± 0.45 | 5.58 |
C8B | −2.26 ± 1.77 | − 1.89 | 5.01 | |
C8G | 3.7 | −1.17 | 3.50 | |
C9 | 5.05 | −1.27 ± 0.23 | 2.60 ± 1.33 | |
Inhibitors | ||||
C1NH | −2.11 ± 1.04 | −1.86 ± 0.21 | 2.23 ± 1.17 | |
C1QBP | 1.77 ± 0.59 | 1.14 ± 0.64 | NA | |
CFI | −1.70 ± 0.44 | −1.34 ± 0.62 | 2.51 ± 0.84 | |
C4BPA | −4.00 ± 2.70 | −1.76 ± 0.74 | 2.08 ± 0.75 | |
Secreted | C4BPB | − 1.42 ± 2.92 | −1 | NA |
CFH | −1.91 ± 0.98 | −0.95 ± 0.21 | 4 | |
CLU | −1.83 ± 0.58 | − 1.76 ± 0.37 | 3.04 ± 0.83 | |
VTN | 3.1 | − 1.44 ± 0.62 | 3.24 | |
VWF | −2.25 ± 0.73 | −2.27 ± 1.06 | NA | |
SERPINA1 | −5.25 ± 1.77 | − 2.01 ± 0.41 | NA | |
SERPINA3 | − 1.37 ± 0.71 | −1.69 ± 0.16 | 2.34 | |
CD55/DAF | − 2.27 ± 1.02 | −2.47 ± 0.43 | NA | |
CD59/MAC | −1.35 ± 0.40 | − 0.97 ± 0.36 | NA | |
CD44 | −1.84 ± 0.81 | −1 | 2.66 | |
CD46/MCP | 1.80 ± 0.14 | NA | 3 | |
CD35/CR1 | −1.48 ± 0.22 | NA | NA | |
CD21/CR2 | 2.07 ± 1.56 | NA | NA | |
Membrane | ITGAM/CR3 | −2.67 ± 0.55 | 1.77 | NA |
ITGAX/CR4 | −2.4 | NA | NA | |
ITGB2/ CR3 | −2.20 ± 0.46 | NA | NA | |
MRC1 | −2.15 ± 0.99 | −2.10 ± 1.22 | 1.27 ± 0.36 | |
C3AR1 | −1.76 ± 0.92 | NA | NA | |
CD88/C5AR1 | −1.84 ± 0.66 | UP | NA | |
VSIG4/C3bR | −1.96 ± 0.69 | NA | NA | |
CD93/C1QR1 | −1.97 ± 0.53 | −2.76 ± 0.93 | NA | |
Regulators | ||||
APOA1 | −0.52 | −2.98 ± 1.35 | 1.71 ± 0.23 | |
APOA2 | −1.7 | −2.64 ± 0.54 | 1.46 | |
APOA4 | NA | −1.10 ± 0.29 | 2.40 ± 0.99 | |
APOB | NA | −1.71 ± 0.79 | 3.16 ± 2.74 | |
APOC1 | −2.11 ± 0.88 | −2.19 ± 0.60 | 1.32 | |
APOC2 | −1.04 | −2.87 ± 0.14 | NA | |
APOC3 | NA | −2.07 ± 0.52 | 0.4 | |
APOD | −1.90 ± 0.80 | −1.28 ± 0.45 | NA | |
APOE | −2.00 ± 0.85 | − 1.15 ± 0.61 | 1.16 ± 0.18 | |
APOL3 | −1.88 ± 1.11 | NA | NA | |
A2M | −2.04 ± 0.99 | −2.63 | 2.43 ± 0.39 | |
SERPINB1 | −2.78 ± 1.30 | NA | NA | |
SERPINB2 | 4.35 ± 3.34 | 5.67 | NA | |
SERPINB5 | 3.73 ± 3.05 | 3.74 | NA | |
SERPIND1 | 1.73 ± 0.24 | −2.43 ± 1.25 | NA | |
SERPINF1 | −1.70 ± 0.00 | −0.2 | NA | |
SERPINH1 | 1.30 ± 0.20 | 2.36 ± 0.09 | NA | |
SERPINI1 | 3.95 ± 1.46 | NA | NA | |
SERBP1 | 1.20 ± 0.00 | 1.47 ± 0.71 | NA |