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Table 7 Univariate analysis of prognostic factors for recurrence-free survival in ICC

From: Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

Variable Univariate analysis
Category Median survival p value Confidence interval
Age < 60 vs. ≥60 19.6 vs. 16.3 0.254 0.827–2.049
Gender Male vs. Female 16.7 vs. 20.0 0.608 0.711–1.793
HBV infection Absent vs. Present 14.8 vs. 23.0 0.009* 0.319–0.847
Preoperative AFP (μg/l) < 9 vs. ≥9 15.3 vs. 25.9 0.658 0.527–1.499
Preoperative CA19–9 (U/ml) < 35 vs. ≥35 22.0 vs. 16.3 0.122 0.897–2.504
Tumor size (mm) < 50 vs. ≥50 25.0 vs. 12.9 0.004* 1.258–3.321
Vascular invasion Absent vs. Present 20.2 vs. 12.0 0.322 0.782–2.116
Lymph node metastasis Absent vs. Present 27.4 vs. 6.8 < 0.001* 1.747–4.538
Tumor number Single vs. Multiple 19.9 vs. 8.3 0.049* 1.002–3.064
Histologic differentiation Well/Moderate vs. Poor 18.0 vs. 18.1 0.727 0.689–1.706
Perineural sheath infiltration Absent vs. Present 14.5 vs. 18.6 0.960 0.522–1.980
Distribution Unilobar vs.Bilobar 20.0 vs. 16.8 0.169 0.867–2.269
TNM stage I/II vs. III/IV 31.0 vs. 7.3 < 0.001* 2.047–5.665
MLVD Low vs. High 30.7 vs. 3.9 < 0.001* 3.442–10.079
  1. *p< 0.05 defined as statistical significance