Table 7 Univariate analysis of prognostic factors for recurrence-free survival in ICC
From: Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma
Variable | Univariate analysis | |||
|---|---|---|---|---|
Category | Median survival | p value | Confidence interval | |
Age | < 60 vs. ≥60 | 19.6 vs. 16.3 | 0.254 | 0.827–2.049 |
Gender | Male vs. Female | 16.7 vs. 20.0 | 0.608 | 0.711–1.793 |
HBV infection | Absent vs. Present | 14.8 vs. 23.0 | 0.009* | 0.319–0.847 |
Preoperative AFP (μg/l) | < 9 vs. ≥9 | 15.3 vs. 25.9 | 0.658 | 0.527–1.499 |
Preoperative CA19–9 (U/ml) | < 35 vs. ≥35 | 22.0 vs. 16.3 | 0.122 | 0.897–2.504 |
Tumor size (mm) | < 50 vs. ≥50 | 25.0 vs. 12.9 | 0.004* | 1.258–3.321 |
Vascular invasion | Absent vs. Present | 20.2 vs. 12.0 | 0.322 | 0.782–2.116 |
Lymph node metastasis | Absent vs. Present | 27.4 vs. 6.8 | < 0.001* | 1.747–4.538 |
Tumor number | Single vs. Multiple | 19.9 vs. 8.3 | 0.049* | 1.002–3.064 |
Histologic differentiation | Well/Moderate vs. Poor | 18.0 vs. 18.1 | 0.727 | 0.689–1.706 |
Perineural sheath infiltration | Absent vs. Present | 14.5 vs. 18.6 | 0.960 | 0.522–1.980 |
Distribution | Unilobar vs.Bilobar | 20.0 vs. 16.8 | 0.169 | 0.867–2.269 |
TNM stage | I/II vs. III/IV | 31.0 vs. 7.3 | < 0.001* | 2.047–5.665 |
MLVD | Low vs. High | 30.7 vs. 3.9 | < 0.001* | 3.442–10.079 |