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Table 5 Univariate analysis of prognostic factors for overall survival in ICC

From: Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

Variable Univariate analysis
Category Median survival p value Confidence interval
Age < 60 vs. ≥60 24.1 vs. 19.9 0.394 0.767–1.961
Gender Male vs. Female 19.3 vs. 26.1 0.074 0.957–2.554
HBV infection Absent vs. Present 20.2 vs. 25.1 0.118 0.411–1.106
Preoperative AFP (μg/l) < 9 vs. ≥9 19.5 vs. 29.4 0.466 0.469–1.414
Preoperative CA19–9 (U/ml) < 35 vs. ≥35 25.1 vs. 20.8 0.075 0.952–2.849
Tumor size (mm) < 50 vs. ≥50 28.4 vs. 17.5 0.003* 1.312–3.631
Vascular invasion Absent vs. Present 24.9 vs. 14.4 0.062 0.976–2.695
Lymph node metastasis Absent vs. Present 30.7 vs. 11.8 < 0.001* 1.916–5.215
Tumor number Single vs. Multiple 23.6 vs. 14.4 0.201 0.815–2.646
Histologic differentiation Well/Moderate vs. Poor 23.1 vs. 21.2 0.561 0.719–1.838
Perineural sheath infiltration Absent vs. Present 22.6 vs. 19.0 0.615 0.608–2.321
Distribution Unilobar vs.Bilobar 23.2 vs. 21.4 0.127 0.894–2.457
TNM stage I/II vs. III/IV 34.3 vs. 12.0 < 0.001* 2.189–6.403
MLVD Low vs. High 34.8 vs. 7.9 < 0.001* 3.963–12.620
  1. *p< 0.05 defined as statistical significance