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Table 5 Univariate analysis of prognostic factors for overall survival in ICC

From: Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

Variable

Univariate analysis

Category

Median survival

p value

Confidence interval

Age

< 60 vs. ≥60

24.1 vs. 19.9

0.394

0.767–1.961

Gender

Male vs. Female

19.3 vs. 26.1

0.074

0.957–2.554

HBV infection

Absent vs. Present

20.2 vs. 25.1

0.118

0.411–1.106

Preoperative AFP (μg/l)

< 9 vs. ≥9

19.5 vs. 29.4

0.466

0.469–1.414

Preoperative CA19–9 (U/ml)

< 35 vs. ≥35

25.1 vs. 20.8

0.075

0.952–2.849

Tumor size (mm)

< 50 vs. ≥50

28.4 vs. 17.5

0.003*

1.312–3.631

Vascular invasion

Absent vs. Present

24.9 vs. 14.4

0.062

0.976–2.695

Lymph node metastasis

Absent vs. Present

30.7 vs. 11.8

< 0.001*

1.916–5.215

Tumor number

Single vs. Multiple

23.6 vs. 14.4

0.201

0.815–2.646

Histologic differentiation

Well/Moderate vs. Poor

23.1 vs. 21.2

0.561

0.719–1.838

Perineural sheath infiltration

Absent vs. Present

22.6 vs. 19.0

0.615

0.608–2.321

Distribution

Unilobar vs.Bilobar

23.2 vs. 21.4

0.127

0.894–2.457

TNM stage

I/II vs. III/IV

34.3 vs. 12.0

< 0.001*

2.189–6.403

MLVD

Low vs. High

34.8 vs. 7.9

< 0.001*

3.963–12.620

  1. *p< 0.05 defined as statistical significance