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Table 2 Spearman’s correlation test for stratification of prognostic subtypes according to the MLVD

From: Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

MLVD n (%) r (95% CI) P (two-paired) P value summary
4 to 4 1 (1.3) NA NA NA
4 to 5 7 (8.9) 0.2041 (NA) 0.5714 NS
4 to 6 11 (13.9) −0.4077 (−0.8166 to 0.2736) 0.1013 NS
4 to 7 16 (20.3) −0.4604 (−0.7847 to 0.0619) 0.0456 *
4 to 8 19 (24.1) −0.5844 (− 0.8255 to − 0.1631) 0.0086 **
4 to 9 23 (29.1) −0.6729 (− 0.8531 to − 0.3494) 0.0004 ***
4 to 10 26 (32.9) −0.6035 (− 0.8074 to − 0.2709) 0.0011 **
4 to 11 27 (34.2) −0.6182 (− 0.8124 to − 0.3005) 0.0006 ***
4 to 12 32 (40.5) −0.6589 (− 0.8229 to − 0.3936) < 0.0001 ****
4 to 13 37 (46.8) −0.6647 (− 0.8169 to − 0.4260) < 0.0001 ****
4 to 14 39 (49.4) −0.6619 (− 0.8119 to − 0.4299) <  0.0001 ****
4 to 15 44 (55.7) − 0.6436 (− 0.7930 to − 0.4212) <  0.0001 ****
4 to 16 48 (60.8) − 0.6377 (− 0.7838 to − 0.4248) < 0.0001 ****
4 to 17 50 (63.3) − 0.6220 (− 0.7709 to − 0.4085) <  0.0001 ****
4 to 18 56 (70.9) − 0.6630 (− 0.7915 to − 0.4784) < 0.0001 ****
4 to 19 60 (75.9) −0.6456 (− 0.7759 to − 0.4624) < 0.0001 ****
4 to 20 68 (86.1) −0.6752 (− 0.7897 to − 0.5152) < 0.0001 ****
4 to 21 69 (87.3) −0.6811 (− 0.7931 to − 0.5247) < 0.0001 ****
4 to 22 72 (91.1) −0.6789 (− 0.7895 to − 0.5256) < 0.0001 ****
4 to 23 76 (96.2) −0.6149 (− 0.7411 to − 0.4466) < 0.0001 ****
4 to 24 76 (96.2) −0.6149 (− 0.7411 to − 0.4466) < 0.0001 ****
4 to 25 79 (100) −0.5966 (− 0.7256 to − 0.4271) < 0.0001 ****
  1. Note: Patients censored before 5 years of follow-up were excluded. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001
  2. Abbreviations: MLVD microlymphatic vessel density CI confidence interval. NA not applicable. NS, not significant