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Table 2 Network meta-analysis results with hazard ratio (HR) for 3-OS, 5-OS, 3-DFS, and 5-DFS, and odds ratio (OR) for 5-OSR

From: Comparative efficacy of six therapies for Hypopharyngeal and laryngeal neoplasms: a network meta-analysis

3-OS

S

0.8 (0.64, 1.00)

0.95 (0.95, 1.68)

1.04 (0.83, 0.30)

0.85 (0.65, 1.11)

0.81 (0.65, 1)

1.25 (1.00, 1.57)

RT

1.19 (0.68, 2.08)

1.31 (1.06, 1.61)

1.07 (0.84, 1.36)

1.02 (0.83, 1.24)

1.06 (0.59, 1.88)

0.84 (0.48, 1.48)

TLM

1.1 (0.61, 1.98)

0.90 (0.49, 1.64)

0.86 (0.48, 1.53)

0.96 (0.77, 1.20)

0.77 (0.62, 0.94)

0.91 (0.51, 1.63)

RT + S

0.82 (0.68, 0.98)

0.78 (0.64, 0.94)

1.18 (0.90, 1.54)

0.94 (0.74, 1.20)

1.11 (0.61, 2.03)

1.22 (1.02, 1.47)

ICRT

0.95 (0.76, 1.20)

1.23 (1.00, 1.53)

0.98 (0.80, 1.21)

1.17 (0.62, 2.09)

1.28 (1.06, 1.55)

1.05 (0.84, 1.32)

CCRT

5-OS

S

0.80 (0.64, 0.99)

0.90 (0.56, 1.45)

1.02 (0.81, 1.27

0.91 (0.69, 1.21)

0.86 (0.68, 1.10)

1.25 (1.01, 1.55)

RT

1.13 (0.71, 1.80)

1.27 (1.01, 1.59)

1.14 (0.87, 1.48)

1.08 (0.86, 1.35)

1.11 (0.69, 1.78)

0.89 (0.56, 1.41)

TLM

1.12 (0.68, 1.85)

1.01 (0.60, 1.69

0.96 (0.58, 1.58)

0.98 (0.79, 1.23)

0.79 (0.63, 0.99)

0.89 (0.54, 1.46)

RT + S

0.90 (0.71, 1.13)

0.85 (0.68, 1.07)

1.10 (0.83, 1.46)

0.88 (0.68, 1.15)

0..99 (0.59, 1.67)

1.12 (0.89, 1.40)

ICRT

0.95 (0.74, 1.22)

1.16 (0.91, 1.47)

0.93 (0.74, 1.16)

1.05 (0.63, 1.72)

1.18 (0.93, 1.48)

1.05 (0.82, 1.35)

CCRT

3-DFS

S

0.93 (0.40, 2.15)

0.45 (0.09, 2.32)

1.73 (0.98, 3.08)

1.76 (0.89, 3.48)

1.67 (0.78, 3.57)

1.08 (0.46, 2.49)

RT

0.49 (0.12, 1.98)

1.86 (0.84, 4.16)

1.89 (0.91, 3.95)

1.79 (1.06, 3.04)

2.21 (0.43, 11.29)

2.05 (0.51, 8.31)

TLM

3.82 (0.76, 19.20)

3.88 (0.80, 18.84)

3.68 (0.82, 16.42)

0.58 (0.32, 1.03)

0.54 (0.32, 1.03)

0.26 (0.05, 1.31)

RT + S

1.01 (0.63, 1.62)

0.96 (0.49, 1.90)

0.57 (0.29, 1.13)

0.53 (0.25, 1.1)

0.26 (0.05, 1.25)

0.99 (0.62, 1.58)

ICRT

0.95 (0.54, 1.67)

0.6 (0.28, 1.28)

0.56 (0.33, 0.94)

0.27 (0.06, 1.21)

1.04 (0.53, 2.05)

1.05 (0.60, 1.86)

CCRT

5-DFS

S

0.98 (0.44, 2.21)

0.66 (0.14, 3.09)

1.44 (0.73, 2.83)

1.20 (0.56, 2.55)

1.33 (0.63, 2.82)

1.02 (0.45, 2.28)

RT

0.67 (0.18, 2.5)

1.46 (0.60, 3.56)

1.21 (0.51, 2.87)

1.35 (0.70, 2.60)

1.51 (0.32, 7.09)

1.49 (0.40, 5.55)

TLM

2.18 (0.45, 10.67)

1.81 (0.38, 8.7)

2.01 (0.46, 8.74)

0.69 (0.35, 1.36)

0.68 (0.28, 1.66)

0.46 (0.09, 2.24)

RT + S

0.83 (0.49, 1.41)

0.92 (0.43, 1.96)

0.84 (0.39, 1.78)

0.82 (0.35, 1.94)

0.55 (0.11, 2.66)

1.21 (0.71, 2.05)

ICRT

1.11 (0.57, 2.16)

0.75 (0.35, 1.60)

0.74 (0.38, 1.43)

0.5 (0.11, 2.16)

1.08 (0.51, 2.30)

0.9 (0.46, 1.74)

CCRT

5-OSR

S

0.78 (0.31, 1.82)

2.08 (0.53, 7.33)

1.28 (0.52, 3.08)

0.94 (0.34, 2.63)

0.93 (0.39, 2.19)

1.29 (0.55, 3.24)

RT

2.71 (0.84, 8.16)

1.66 (0.61, 4.68)

1.22 (0.45, 3.47)

1.20 (0.51, 2.99)

0.48 (0.14, 1.87)

0.37 (0.12, 1.20)

TLM

0.61 (0.15, 2.79)

0.45 (0.11, 2.14)

0.44 (0.12, 1.84)

0.78 (0.32, 1.91)

0.60 (0.21, 1.64)

1.64 (0.36, 6.57)

RT + S

0.73 (0.28, 1.89)

0.73 (0.28, 1.85)

1.06 (0.38, 2.97)

0.82 (0.29, 2.24)

2.24 (0.47, 9.15)

1.37 (0.53, 3.55)

ICRT

0.99 (0.44, 2.18)

1.07 (0.46, 2.57)

0.83 (0.33, 1.95)

2.25 (0.54, 8.40)

1.38 (0.54, 3.57)

1.01 (0.46, 2.28)

CCRT

  1. Note: Figures in bold font show significant outcome
  2. Abbreviation: S surgery, RT radiotherapy, TLM transoral laser microsurgery, RT + S surgery combined with radiotherapy, ICRT Induction chemotherapy radiotherapy, CCRT current chemotherapy radiotherapy, 3-OS 3-year overall survival, 5-OS 5-year overall survival, 3-DFS 3-year disease free survival, 5-DFS 5-year disease free survival;5-OSR, 5-year overall survival rate