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Table 1 Basic characteristics of included studies

From: Comparative efficacy of six therapies for Hypopharyngeal and laryngeal neoplasms: a network meta-analysis

Study

Design

Cancer type

Stage

No. of patients

Comparison

Wolf, 2017

Retrospective

Glottic/supraglottic cancer

I-IV

247

RT vs. CCRT vs. S

Stokes, 2017

Retrospective

Larynx cancer

IV

3542

RT + S vs. CCRT vs. ICRT

Low, 2017

Retrospective

Laryngeal SCC

I

105

TLM vs. RT

Peng, 2016

Retrospective

Glottic cancer

I-II

172

RT vs. S

Marchiano, 2016

Retrospective

Subglottic SCC

I-IV

576

RT vs. S vs. RT + S

De Santis, 2016

Retrospective

Glottic cancer

I-II

75

TLM vs. RT

Timmermans, 2015

Retrospective

Laryngeal cancer

III-IV

182

S vs. CCRT vs. RT

Timme, 2015

Retrospective

Laryngeal cancer

III-IV

71

S vs. CCRT

Li, 2015

Retrospective

Laryngeal cancer

I-IV

309

RT vs. S vs. RT + S

Grover, 2015

Retrospective

Larynx cancer

IV

969

S vs. CCRT

Hsin, 2014

Retrospective

Laryngeal cancer

IV

62

S vs. CCRT

Lefebvre, 2013

Randomized

Larynx/Hypopharynx SCC

II-IV

118

CCRT vs. ICRT

Forastiere, 2013

Randomized

Larynx cancer

III-IV

520

CCRT vs. ICRT vs. RT

Lefebvre, 2012

Randomized

Hypopharyngeal SCC

II-IV

194

RT + S vs. ICRT

Patel, 2011

Retrospective

Larynx cancer

IV

34

CCRT vs. S

Mahler, 2010

Retrospective

Glottic cancer

I

351

RT vs. TLM

Dinapoli, 2010

Retrospective

Glottic cancer

I-II

143

RT vs. S

Schrijvers, 2009

Retrospective

Glottic laryngeal cancer

I

100

RT vs. TLM

Thurnher, 2008

Retrospective

Glottic laryngeal SCC

I

337

S vs. TLM vs. RT

Boscolo-Rizzo, 2008

Retrospective

Laryngeal cancer

III-IV

112

RT + S vs. CCRT

Andreadis, 2007

Retrospective

Laryngeal cancer

III-IV

50

ICRT vs. CCRT

Bensadoun, 2006

Randomized

Laryngeal cancer

III-IV

163

RT vs. CCRT

Richard, 1998

Randomized

Laryngeal cancer

III-IV

68

RT + S vs. ICRT

Beauvillain, 1997

Randomized

Hypopharyngeal cancer

III-IV

90

RT + S vs. S

Bryant, 1995

Retrospective

Glottic cancer

III

97

RT vs. RT + S

Frank, 1994

Retrospective

Hypopharyngeal SCC

I-IV

109

S vs. RT + S

Jones, 1992

Retrospective

Larynx cancer

III-IV

147

S vs. RT + S

Wolf, 1991

Randomized

Larynx cancer

III-IV

166

ICRT vs. CCRT

  1. Abbreviation: S surgery, RT radiotherapy, TLM transoral laser microsurgery, RT + S surgery combined with radiotherapy, ICRT Induction chemotherapy radiotherapy, CCRT, current chemotherapy radiotherapy