Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia

Fig. 4

Methylome analysis of SEM cells. a The Venn diagram shows the number of hypomethylated genes after 48 h incubation with 5 μM CX-4945, 0.1 μM DEC or both compared to DMSO. Methylation data was normalized using quantile normalization and only changes in methylation of at least 4-fold were considered relevant. b Hypomethylated genes were assigned to Gene Ontology (GO) Terms. The chord plot shows the association between the top 7 enriched GO terms and top 30 hypomethylated genes. Genes were further classified by their fold change compared to control cells (blue rectangle). CX-4945 incubation mainly influenced genes annotated by GO terms relating to metabolic processes. FBXO5 and RPS6KA2 have an association to all seven selected GO terms. c Average linking hierarchical clustering of the top-10 regulated biological processes of each treatment was performed and visualized in a heatmap based on statistical significance (−10log p-values)

Back to article page