Table 4 Comparison of protein expression between breast cancer tissues and their matched adjacent tissues
Luminal A (n = 81) | Basal-like (n = 40) | |||||||
|---|---|---|---|---|---|---|---|---|
Adjacent IHS median (range) | Breast cancer IHS median (range) | Z | p | Adjacent IHS median (rang) | Breast cancer IHS median (range) | Z | p | |
β2M | 0 (0–5.4) | 5 (3–6.4) | − 2.847 | 0.004 | 2 (0–5.4) | 5 (0–7) | − 2.090 | 0.037 |
HIF-1α | 5.1 (4–6) | 5.6 (5–6) | − 2.160 | 0.031 | 5 (0–6.2) | 5.2 (3–5.8) | −1.336 | 0.181 |
p-CREB | 5.33 (3.5–6.2) | 6.5 (5.3–7) | − 3.434 | 0.001 | 5.7 (4–6.6) | 5.95 (2.7–6.5) | −0.345 | 0.730 |
VEGF | 0 (0–6) | 5.8 (3–6.8) | − 3.469 | 0.001 | 2.5 (0–5.4) | 5.5 (3.2–6.0) | −2.867 | 0.004 |
p-SGK1 | 5.1 (0–7) | 5.9 (5.1–6.4) | −2.272 | 0.023 | 6 (4.3–6.5) | 5.9 (5–6.2) | −0.677 | 0.498 |
p-ERK1/2 | 4.55 (0–6.3) | 6.1 (5–6.8) | −2.858 | 0.004 | 5.2 (3–6.2) | 5.64 (4.4–6.5) | −1.098 | 0.272 |
Bcl-2 | 0 (0–5) | 3.9 (0–5.4) | −2.483 | 0.013 | 0 (0–5) | 5 (0–5.4) | −3.083 | 0.002 |