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Table 1 Reported cases of pneumatosis intestinalis in patients with lung cancer who received treatment with EGFR-TKIs

From: Pneumatosis intestinalis induced by osimertinib in a patient with lung adenocarcinoma harbouring epidermal growth factor receptor gene mutation with simultaneously detected exon 19 deletion and T790 M point mutation: a case report

Drug First author Publication year Age/sex Treatment Symptoms Complication Outcome Restart of EGFR-TKI treatment Recurrence
Gefitinib Higashino (7) 2010 67/F Observation/withdrawal Mild abdominal pain Intra-peritoneal free air Improved ND
Gefitinib Iwasaku (8) 2012 82/F Observation/withdrawal Mild abdominal pain None Improved Yes Yes
Gefitinib Lee (9) 2012 66/F Observation/withdrawal Vomiting, diarrhea, and abdominal distension Intra-hepatic portal veinous gas with suggestive of liver infarction Improved No
Gefitinib Wakabayashi (10) 2012 83/M Surgery/ withdrawal Fever, vomiting, diarrhea, and severe abdominal pain Intra-peritoneal free air, remarkable elevation of inflammatory parameters Improved ND
Gefitinib Otsubo (11) 2015 71/M Observation/withdrawal Vomiting, diarrhea, and abdominal pain Intra-peritoneal free air Improved Yes No
Gefitinib Maeda (12) 2016 80/F Observation/withdrawal Anorexia, constipation, and abdominal distension Intra-peritoneal free air, mild elevation of inflammatory parameters Improved Yes Yes
Erlotinib + bevacizumab Tsukita (13) 2014 69/M Observation/withdrawal No symptoms Intra-peritoneal free air Improved ND
Erlotinib + pemetrexed Yamamoto (14) 2014 70/F Observation, continuation of erlotinib Vomiting, anorexia, diarrhea, and abdominal pain None Improved
Erlotinib + bevacizumab Saito (15) 2016 73/F Observation/withdrawal Anorexia and fatigue Intra-peritoneal free air Improved No
Osimertinib Current case 2018 73/F Observation/withdrawal No symptoms Intra-hepatic portal vein gas Improved Yes No
  1. Abbreviations: EGFR-TKI epidermal growth factor receptor tyrosine kinase inhibitor, F female, M male, ND not described