Skip to main content

Table 1 Reported cases of pneumatosis intestinalis in patients with lung cancer who received treatment with EGFR-TKIs

From: Pneumatosis intestinalis induced by osimertinib in a patient with lung adenocarcinoma harbouring epidermal growth factor receptor gene mutation with simultaneously detected exon 19 deletion and T790 M point mutation: a case report

Drug

First author

Publication year

Age/sex

Treatment

Symptoms

Complication

Outcome

Restart of EGFR-TKI treatment

Recurrence

Gefitinib

Higashino (7)

2010

67/F

Observation/withdrawal

Mild abdominal pain

Intra-peritoneal free air

Improved

ND

Gefitinib

Iwasaku (8)

2012

82/F

Observation/withdrawal

Mild abdominal pain

None

Improved

Yes

Yes

Gefitinib

Lee (9)

2012

66/F

Observation/withdrawal

Vomiting, diarrhea, and abdominal distension

Intra-hepatic portal veinous gas with suggestive of liver infarction

Improved

No

Gefitinib

Wakabayashi (10)

2012

83/M

Surgery/ withdrawal

Fever, vomiting, diarrhea, and severe abdominal pain

Intra-peritoneal free air, remarkable elevation of inflammatory parameters

Improved

ND

Gefitinib

Otsubo (11)

2015

71/M

Observation/withdrawal

Vomiting, diarrhea, and abdominal pain

Intra-peritoneal free air

Improved

Yes

No

Gefitinib

Maeda (12)

2016

80/F

Observation/withdrawal

Anorexia, constipation, and abdominal distension

Intra-peritoneal free air, mild elevation of inflammatory parameters

Improved

Yes

Yes

Erlotinib + bevacizumab

Tsukita (13)

2014

69/M

Observation/withdrawal

No symptoms

Intra-peritoneal free air

Improved

ND

Erlotinib + pemetrexed

Yamamoto (14)

2014

70/F

Observation, continuation of erlotinib

Vomiting, anorexia, diarrhea, and abdominal pain

None

Improved

Erlotinib + bevacizumab

Saito (15)

2016

73/F

Observation/withdrawal

Anorexia and fatigue

Intra-peritoneal free air

Improved

No

Osimertinib

Current case

2018

73/F

Observation/withdrawal

No symptoms

Intra-hepatic portal vein gas

Improved

Yes

No

  1. Abbreviations: EGFR-TKI epidermal growth factor receptor tyrosine kinase inhibitor, F female, M male, ND not described