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Fig. 5 | BMC Cancer

Fig. 5

From: Increased NHE1 expression is targeted by specific inhibitor cariporide to sensitize resistant breast cancer cells to doxorubicin in vitro and in vivo

Fig. 5

Cariporide enhances the sensitivity of cancerous tumors to doxorubicin in vivo. (a) Tumor tissues from each group were stained with H&E, while NHE1, cleaved PARP and caspase-3 expression in the tumor sections was characterized by immunohistochemistry. (b) Tissue lysates were subsequently prepared and subjected to western blotting analysis using the indicated antibodies. (c-e) Relative expression of MDR1, Bcl-2, and cleaved caspase-3 is shown in the histogram

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