IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study

BMC Cancer

Table 1 Basic information and allele frequencies of the five selected SNPs

SNP_ID	Gene	Chromosome	Position	Allele	Minor allele frequency		HWE p value	OR (95% CI)	p ^a
SNP_ID	Gene	Chromosome	Position	Allele	Case	Control	HWE p value	OR (95% CI)	p ^a
rs3783550	IL1A	2q13	113,532,885	T/G	0.358	0.326	0.399	1.15 (0.91–1.45)	0.222
rs3783546	IL1A	2q13	113,534,830	C/G	0.353	0.325	0.458	1.13 (0.90–1.42)	0.296
rs2856838	IL1A	2q13	113,539,972	A/G	0.256	0.247	0.319	1.04 (0.81–1.35)	0.716
rs1609682	IL1A	2q13	113,540,205	T/G	0.354	0.327	0.398	1.12 (0.90–1.42)	0.298
rs3783521	IL1A	2q13	113,543,577	G/A	0.356	0.326	0.399	1.14 (0.91–1.44)	0.252

SNP Single nucleotide polymorphism, HWE Hardy-Weinberg equilibrium, OR Odds ratio, 95% CI, 95% confidence interval
HWE p-value obtained from Fisher’s exact test (p > 0.05)
p^a values were calculated from Pearson’s χ² test regarding to the allele distribution frequencies among CRC patients and healthy controls
p < 0.05 indicates SNP with statistical significance

ISSN: 1471-2407