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Table 2 Clinical features of SCC transformation in MCTO from a retrospective chart review

From: Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Case Age (years) Symptoms Elevated tumor marker Diameter (cm) Surgery Optimal debulking Rupture Grade Stage Adjuvant therapy Follow-up (status, months)
1 ≥45 Accidental finding 7 TH + LSO + BPLND + omentectomy Y N 3 IA TC × 1 LOST, 3
2 ≥45 Pain CA125(179.5 U/mL), CEA (6.1 ng/mL) 12 TH + BSO + omentectomy + BPLND + BPALND + peritoneal tumor resection Y N 2 IIB TC × 6 NED, 72
3 ≥45 Pain, distension CA125(363.8 U/mL), CEA (25.2 ng/mL) 15 TH + BSO + appendectomy Y N 2 IIIB TC × 1 DOD, 9
4 ≥45 Pain, distension, fever CA125(62.9 U/mL), SCC (7.3 ng/mL) 20 TH + BSO + omentectomy + partial peritoneal resection N Preoperative 2 IIIC LOST, 24
5 ≥45 Pain, vaginal bleeding CA125(144.7 U/mL), SCC (15.1 ng/mL), CA199(119.1 U/mL), CEA (40.9 ng/mL) 25 TH + BSO + tumor resection + sigmoidectomy N Intraoperative 3 IIIC DOD, 15
6 <45 Accidental finding CA125 (42.8 U/mL), CA199(97.1 U/mL) 5 Initial surgery: Left ovarian cystectomy
Restaging surgery: LSO + omentectomy + BPLND + BPALND
Y N 3 IC TC × 3 NED, 8
  1. TH total hysterectomy, LSO left salpingo-oophorectomy, BSO bilateral salpingo-oophorectomy, BPLND bilateral pelvic lymph node dissection, BPALND bilateral para-aortic lymph node dissection, TC taxol/carboplatin, Y yes, N no, DOD die of disease, NED no evidence of disease