Table 3 Clinical characteristics of patients in the METABRIC cohort with Luminal A breast cancer, classified by DISTANCE RATIO purity
| Â | Distance ratio tertiles | |||
|---|---|---|---|---|
T1 n = 223 | T2 n = 222 | T3 n = 229 | P, T1 vs T3 | |
Age, years (mean) | 60.0 | 63.0 | 65.2 | <.001 |
Menopausal status (%) | ||||
 Pre-menopausal | 26% | 17% | 13% | < 0.001 |
 Post-menopausal | 74% | 83% | 87% | – |
ER+ (%) | 79% | 75% | 75% | 0.372 |
PR+ (%) | 54% | 55% | 53% | 0.851 |
HER2+ (%) | 13% | 10% | 16% | 0.258 |
ER+ or PR+, HER2-, and Low proliferation | 67% | 49% | 33% | < 0.001 |
Tumor size | ||||
 mm (mean)a | 21.7 | 24.8 | 24.9 | 0.001 |
  < 20 mm (%) | 46% | 34% | 28% | < 0.001 |
  > 20 mm (%) | 54% | 66% | 72% | – |
Grade (mean) | ||||
 score (mean) | 1.86 | 2.05 | 2.32 | < 0.001 |
  < 3 (%) | 81% | 73% | 59% | < 0.001 |
  = 3 (%) | 13% | 23% | 38% | – |
Node positive (%) | 37% | 41% | 49% | 0.014 |
Stage (%) | ||||
 I | 53% | 42% | 38% | 0.006 |
 II-III-IV | 47% | 58% | 62% | – |