Table 2 Clinical characteristics of patients in the METABRIC cohort with Luminal A breast cancer, classified by MEDIAN DISTANCE PURITY criteria
| Â | Median distance criteria | ||||
|---|---|---|---|---|---|
All cases n = 674 | Pure n = 143 | Neither n = 288 | Admixed n = 243 | P, Pure vs Admixed | |
Age, years (mean) | 62.8 | 58.9 | 63.3 | 64.5 | <.001 |
Menopausal status (%) | |||||
 Pre-menopausal | 19% | 29% | 16% | 16% | < 0.001 |
 Post-menopausal | 81% | 71% | 84% | 84% | – |
ER+ (%) | 76% | 79% | 75% | 76% | 0.533 |
PR+ (%) | 54% | 52% | 53% | 56% | 0.459 |
HER2+ (%) | 13% | 11% | 14% | 13% | 0.525 |
ER+ or PR+, HER2-, and Low proliferationa | 49% | 65% | 41% | 49% | 0.003 |
Tumor size | |||||
 mm (mean) | 23.8 | 23.3 | 24.3 | 23.6 | 0.775 |
  < 20 mm (%) | 36% | 46% | 34% | 33% | 0.012 |
  > 20 mm (%) | 64% | 54% | 66% | 67% | – |
Grade (mean)b | |||||
 score (mean) | 2.08 | 1.85 | 2.13 | 2.14 | < 0.001 |
  < 3 (%) | 71% | 79% | 67% | 70% | 0.057 |
  = 3 (%) | 25% | 16% | 28% | 26% | – |
Node positive (%) | 42% | 38% | 40% | 48% | 0.056 |
Stage (%)c | |||||
 I | 44% | 52% | 45% | 39% | 0.026 |
 II-III-IV | 56% | 48% | 55% | 61% | – |