Table 1 Baseline patient characteristics of the included studies
References | No. | Sex (M/F) | Median age (years, range) | No. of PV | No. of ET | No. of PMF | Thrombotic outcome | Bleeding outcome | Study period | Type |
|---|---|---|---|---|---|---|---|---|---|---|
Fenaux 1990 [7] | 147 | 60/87 | 60 (18–83) | – | 147 | – | Yes (A + V) | Yes | 1970–1987 | R |
Colombi 1991 [8] | 103 | 44/59 | 59 (9–88) | – | 103 | – | Yes (A + V) | Yes | 1975–1990 | R |
Besses 1999 [9] | 148 | 53/95 | 60.5 (11–85) | – | 148 | – | Yes (A + V) | Yes | 1979–1994 | R |
Manoharan 1999 [10] | 61 | PV: 10/ 10 ET: 10/ 20 PMF: 5/ 6 | PV: 76 (54–84) ET: 71 (25–88) PMF: 74 (31–84) | 20 | 30 | 11 | Yes (A + V) | No | 1993–1997 | P |
Jensen 2000 [11] | 96 | 27/69 | 67 (18–87) | – | 96 | – | Yes (A + V) | Yes | 1977–1998 | R |
Passamonti 2000 [12] | 163 | 98/65 | 57 (30–82) | 163 | – | – | Yes (A + V) | Yes | 1975–1997 | R |
Chim 2005 [13] | 231 | 112/119 | 65 (18–90) | – | 231 | – | Yes (A + V) | Yes | NR | R |
Marchioli 2005 [14] | 1638 | 942/ 696 | 60.4 | 1638 | – | – | Yes (A + V) | Yes | NR | P |
Cervantes 2006 [15] | 155 | 97/ 58 | 65 (17–89) | – | – | 155 | Yes (A + V) | No | 1972–2005 | R |
Wolanskyj 2006 [16] | 322 | 104/ 218 | 54 (12–88) | – | 322 | – | Yes (A + V) | Yes | 1956–1992 | R |
Carobbio 2007 [17] | 439 | 175/ 264 | 54 (10–93) | – | 439 | – | Yes (A + V) | No | 1981–2006 | R |
Vannucchi 2007 [18] | 962 | PV: 176/ 147 ET: 202/ 437 | NR | 323 | 639 | – | Yes (A + V) | No | NR | R |
Bang 2009 [19] | 283 | 143/ 140 | 61 | 120 | NR | NR | Yes (A + V) | Yes | 2006–2007 | P |
Barbui 2010 [20] | 707 | 465/ 242 | 62 (11–90) | – | – | 707 | Yes (A + V) | No | 1973–2008 | R |
Elliott 2010 [21] | 205 | 131/ 74 | 62 (28–87) | – | – | 205 | Yes (A + V) | No | 1982–2008 | R |
Palandri 2011 [22] | 532 | 205/ 327 | 64 (16–95) | – | 532 | – | Yes (A + V) | No | 1978–2008 | R |
Buxhofer-Ausch 2012 [23] | 264 | 109/ 155 | 57.4 | – | – | 264 | Yes (A + V) | No | NR | P |
Finazzi 2012 [24] | 1104 | ET: 370/ 521 PMF: 74/ 106 | ET: 55.7 (12.9–91) PMF: 57.4 (20.9–87.7) | – | 891 | 180 | No | Yes | NR | P |
Angona 2015 [25] | 214 | 57/ 157 | 64 (9–93) | – | 214 | – | Yes (A + V) | No | 1985–2012 | R |
Enblom 2015 [26] | 612 | PV: 131/ 118 ET: 117/ 155 PMF: 47/ 44 | PV: 69 ET: 67 PMF: 71 | 249 | 272 | 91 | Yes (A + V) | Yes | 1995–2013 | R |
Lim 2015 [27] | 102 | 54/ 48 | 64 (24–87) | 33 | 69 | – | Yes (A) | Yes | 2004–2012 | R |
Duangnapasatit 2015 [28] | 157 | PV: 46/ 22 ET: 32/ 51 PMF: 4/ 2 | PV: 59.6 (18–88) ET: 61.1 (21–89) PMF: 68.3 (52–78) | 68 | 83 | 6 | Yes (A + V) | Yes | 2003–2013 | R |
Kaifie 2016 [29] | 454 | 232/ 222 | 60 | 142 | 140 | 113 | Yes (A + V) | Yes | NR | P |
Cerquozzi 2017 [30] | 587 | 284/ 303 | 60 (17–94) | 587 | – | – | Yes (A + V) | No | NR | P |
Abdulkarim 2017 [31] | 2389 | PV: 548/557 ET: 534/750 | PV: 69 (17–98) ET: 68 (13–94) | 1105 | 1284 | – | Yes (A + V) | Yes | 2008–2015 | R |
Soyer 2017 [32] | 708 | PV: 132/ 81 ET: 151/ 239 PMF: 56/ 49 | PV: 47.5 (17–86) ET: 41.5 (17–89) PMF: 69.5 (19–87) | 213 | 390 | 105 | Yes (A + V) | Yes | 1987–2014 | R |
Bertozzi 2017 [33] | 253 | NR | NR | 124 | 121 | 8 | Yes (A) | Yes | 1978–2016 | R |
Zhou 2018 [34] | 150 | 67/ 83 | 61 (41–71) | – | 150 | – | Yes (A + V) | No | 2013–2016 | P |
Hintermair 2018 [35] | 250 | 152/ 98 | NR | NR | NR | NR | Yes (A + V) | No | 2008–2015 | R |