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Table 1 Clinical characteristic according to PI3KCA mutation status

From: Chronological occurrence of PI3KCA mutations in breast cancer liver metastases after repeat partial liver resection

NN First hepatectomy Second hepatectomy Third hepatectomy
No Mutation Mutation No Mutation Mutation No Mutation Mutation
N = 8 N = 5 N = 11 N = 6 N = 2 N = 2
Hepatic metastases
 Mean age at resection + SD Years 42 + 7 44 + 7   51 + 11 50 + 12   63 + 18 42 + 4
 Mean interval between primary removal and liver resection + SD Months 42 + 20 47 + 37   43 + 21 46 + 33   28 + 9 22 + 9
 Mean number of BCLM diagnosed + SD Distribution + 2 + 2  + 2 + 1      
  Unilateral 5 50% 4 80%   9 82% 4 67%   1 50% 1 100%
  Bilateral 5 50% 1 20%   2 18% 2 33%   1 50% 0 0%
 Concomitant extra-hepatic disease
  No 10 91% 4 80%   8 73% 4 67%   1 50% 1 100%
  Yes 1 9% 1 20%   3 27% 2 33%   1 50% 0 0%
 Chemotherapy before liver resection               
  No 2 18% 1 20%   0 0% 1 17%   0 0% 0 0%
  Yes 9 82% 4 80%   11 100% 5 83%   2 100% 2 100%
 Hormonal Therapy before liver resection
  No 8 73% 2 40%   2 18% 2 33%   1 50% 0 0%
  Yes 3 27% 3 60%   9 82% 4 67%   1 50% 2 100%
 Targeted Therapy before liver resection **    
  No 7 64% 4 80%   2 18% 5 83%   1 50% 2 100%
  Yes 4 36% 1 20%   9 82% 1 17%   1 50% 0 0%
Histopathological characteristics
 Mean maximum resected tumor size + SD, mm 17 + 15 33 + 15 * 21 + 16 26 + 12   19 + 8 23 + 11
 Resection margin***
  R0 8 89% 3 60%   8 80% 4 67%   0 0% 2 100%
  R1 1 11% 2 40%   2 20% 2 33%   1 100% 0 0%
 Microscopic intrahepatic invasion
  No 6 60% 1 20%   7 64% 2 33%    0 0%
  Yes 4 40% 4 80%   4 36% 4 67%    2  
 Cell surface receptors status
  Estrogen
   Negative 0 0% 2 40%   4 36% 2 33%   0 0% 1 50%
   Positive 8 100% 3 60%   7 64% 4 67%   2 100% 1 50%
  Progesterone
   Negative 5 63% 4 80%   6 55% 2 33%   1 50% 1 50%
  Positive 3 38% 1 20%   5 45% 4 67%   1 50% 1 50%
  Her2/Neu
   Negative 6 75% 4 80%   6 60% 4 67%   0 0% 2 100%
   Positive 2 25% 1 20%   4 40% 2 33%   1 100% 0 0%
 Differentiation
  Well differentiated 0 0% 1 20%   1 14% 2 40%   1 50% 0 0%
  Moderately differentiated 5 71% 4 80%   3 43% 2 40%   0 0% 1 50%
  Poorly differentiated 2 29% 0 0%   3 43% 1 20%   1 50% 1 50%
  1. * P < 0.1 ** P < 0.05 *** R0: complete surgical resection with a negative surgical margin at histopathology; R1: invaded surgical margins