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Table 2 Covariates selected for modeling each transition (Eqs. 13) and their estimated regression coefficients expressed as hazard ratios

From: The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases

Transition Treatment to local failure (1) Treatment to death (2) Local failure to Death (3)
Covariates exp(β) 95% CI p-value exp(β) 95% CI p-value exp(β) 95% CI p-value
Sex: Female     0.97 0.65–1.44 0.867    
Age ≥ 66     1.13 0.75–1.69 0.564    
KPS ≥ 90     0.47 0.29–0.78 0.0037 1.30 0.56–3.02 0.534
Tumor site: Lung 0.42 0.25–0.70 0.0010 0.89 0.56–1.41 0.611 1.30 0.56–3.05 0.537
Solitary metastasis: Yes     0.83 0.53–1.29 0.405 0.55 0.23–1.30 0.174
Number of treated metastases > 1     0.96 0.59–1.56 0.861    
Chemotherapy prior to SBRT: Yes 3.64 1.58–8.36 0.0024 1.19 0.71–1.98 0.508 0.19 0.04–0.84 0.028
Tumor volume 1.20 0.89–1.63 0.232 1.99 1.47–2.69 < 0.0001 2.12 1.25–3.58 0.0053
Motion management: Advanced 0.81 0.49–1.34 0.411       
Dose calculation: Advanced 0.86 0.55–1.34 0.497       
BEDiso 0.39 0.25–0.64 0.00013       
  1. If a variable was not used as a covariate for modeling the hazard of a particular transition, its corresponding cell has been left empty. For Transition (2), tumor volume refers to the maximum tumor volume of all treated metastases within a particular patient
  2. KPS Baseline Karnofsky performance status