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Table 1 Variables and outcomes in our sample of 500 CRC metastases

From: The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases

Covariates and outcomes

n

Value

Liver

Lung

p-value

Sex

388

    

Male

271

69.8

72.2

65.4

0.200

Female

117

30.2

27.8

34.6

 

Age [years]

388

66 (24–93)

66 (24–93)

70 (38–36)

0.00399

Baseline Karnofsky index

283

    

 < 90

97

34.2

30.6

40.9

0.125

 ≥90

186

65.7

69.4

59.1

 

Solitary metastasis

304

    

 Yes

110

36.2

33.2

40.7

0.184

 No

194

63.8

66.8

59.3

 

Number of treated metastases

388

    

 1

321

82.7

89.4

69.9

 

 2

42

10.8

8.2

15.8

 

 3

13

3.4

1.6

6.8

 

 4

7

1.8

0.4

4.5

 

 5

2

0.5

0.4

0.7

 

 6

3

0.8

0

2.3

 

Tumor site

500

    

Liver

291

58.2

   

Lung

209

41.8

   

Tumor volume [ccm] (gross tumor volume, GTV)

342

9.20 (0.07–699)

26.0 (0.8–699)

3.1 (0.07–268)

< 0.0001

Chemotherapy prior to SBRT

430

    

Yes

332

77.2

84.5

68.5

< 0.0001

No

98

22.8

15.5

31.5

 

Dose calculation algorithm

496

    

Pencil beam

199

40.1

56.4

17.7

< 0.0001

Advanced

297

59.9

43.6

82.3

Motion management

500

    

Free breathing

347

69.4

75.3

73.7

0.755

Advanced

153

30.6

24.7

26.3

 

BEDiso [Gy10]

500

126.9 (37.5–309.4)

124.8 (37.5–234.5)

141.1 (39.4–309.4)

< 0.0001

Outcomes

388

    

Local failure and censored prior to death

28

7.2

7.5

6.8

< 0.0001

Local failure and death

71

18.3

24.3

6.8

 

Death without local failure

133

34.3

36.5

30.0

 

Censored prior to local failure or death

156

40.2

31.8

56.4

 
  1. Values for continuous variables are given as median (range), those for categorical variables as frequencies in percent. The p-values refer to testing for differences between liver and lung metastases with respect to the variable specified in each row. The Wilcoxon rank sum test and Fisher’s exact test were used to compare continuous and categorical variables, respectively. The variable “solitary metastasis” was coded as “yes” if only lung or liver was involved by a singular metastasis. Beyond this information, the exact location and number of additional metastases has not been encoded