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Table 1 Variables and outcomes in our sample of 500 CRC metastases

From: The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases

Covariates and outcomes n Value Liver Lung p-value
Sex 388     
Male 271 69.8 72.2 65.4 0.200
Female 117 30.2 27.8 34.6  
Age [years] 388 66 (24–93) 66 (24–93) 70 (38–36) 0.00399
Baseline Karnofsky index 283     
 < 90 97 34.2 30.6 40.9 0.125
 ≥90 186 65.7 69.4 59.1  
Solitary metastasis 304     
 Yes 110 36.2 33.2 40.7 0.184
 No 194 63.8 66.8 59.3  
Number of treated metastases 388     
 1 321 82.7 89.4 69.9  
 2 42 10.8 8.2 15.8  
 3 13 3.4 1.6 6.8  
 4 7 1.8 0.4 4.5  
 5 2 0.5 0.4 0.7  
 6 3 0.8 0 2.3  
Tumor site 500     
Liver 291 58.2    
Lung 209 41.8    
Tumor volume [ccm] (gross tumor volume, GTV) 342 9.20 (0.07–699) 26.0 (0.8–699) 3.1 (0.07–268) < 0.0001
Chemotherapy prior to SBRT 430     
Yes 332 77.2 84.5 68.5 < 0.0001
No 98 22.8 15.5 31.5  
Dose calculation algorithm 496     
Pencil beam 199 40.1 56.4 17.7 < 0.0001
Advanced 297 59.9 43.6 82.3
Motion management 500     
Free breathing 347 69.4 75.3 73.7 0.755
Advanced 153 30.6 24.7 26.3  
BEDiso [Gy10] 500 126.9 (37.5–309.4) 124.8 (37.5–234.5) 141.1 (39.4–309.4) < 0.0001
Outcomes 388     
Local failure and censored prior to death 28 7.2 7.5 6.8 < 0.0001
Local failure and death 71 18.3 24.3 6.8  
Death without local failure 133 34.3 36.5 30.0  
Censored prior to local failure or death 156 40.2 31.8 56.4  
  1. Values for continuous variables are given as median (range), those for categorical variables as frequencies in percent. The p-values refer to testing for differences between liver and lung metastases with respect to the variable specified in each row. The Wilcoxon rank sum test and Fisher’s exact test were used to compare continuous and categorical variables, respectively. The variable “solitary metastasis” was coded as “yes” if only lung or liver was involved by a singular metastasis. Beyond this information, the exact location and number of additional metastases has not been encoded