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Table 1 Fold changes of EMT and stem cell markers induced by hypoxia using next-generation sequencing

From: Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation

 

Fold change

Gene volume

Gene

BEAS-2B

A549

BEAS-2B

A549

EMT related

 E-cadherin

−2.321846

−1.24658

2.862953

4.882581

 N-cadherin

1.082626

1.331658

3.891183

3.008228

 Fibronectin

1.51678

2.074191

5.21957

5.292675

 Vimentin

2.461523

2.649509

9.833378

9.097426

 α-SMA

5.27888

4.027409

2.37067

1.848955

 Slug

3.376403

2.962488

1.422036

0.659522

 Snail

2.064503

2.359432

2.745241

2.941692

 Twist1

−1.065424

−1.4102

1.543533

0.969468

 Twist2

− 1.493418

− 1.6265

2.778423

2.162327

 ZEB1

1.949302

2.012616

2.478841

1.987502

 ZEB2

1.325055

1.536987

1.286106

0.96196

 ZO-1

−1.053172

1.168809

4.765156

4.477092

Stem cell related

 CD44

1.983674

1.908933

6.979291

6.502286

 CXCR4

11.88424

6.338601

1.237284

1.165821

 ABCG2

−1.958694

−2.58677

1.357162

2.001303

 ALDH1A1

−4.519745

−3.31873

10.49759

10.74185

 EpCAM

−1.988084

−1.49956

1.015211

4.758595

 CD90

−1.252799

−1.08908

0.732683

0.177706

 Nanog

−1.023746

−1.06456

0.036569

0.044168

 SOX2

−1.850566

−2.22392

0.491689

0.956587

 SSEA4

−1.451824

−1.24891

1.488286

1.510724

 CD166

1.117535

1.219265

5.011018

5.161295

 BMI-1

1.800887

1.659949

3.508488

3.755616

  1. EMT and stem cell markers more than 2–fold changes were marked in bold
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BMC Cancer

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