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Table 1 Fold changes of EMT and stem cell markers induced by hypoxia using next-generation sequencing

From: Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation

  Fold change Gene volume
Gene BEAS-2B A549 BEAS-2B A549
EMT related
E-cadherin −2.321846 −1.24658 2.862953 4.882581
 N-cadherin 1.082626 1.331658 3.891183 3.008228
Fibronectin 1.51678 2.074191 5.21957 5.292675
Vimentin 2.461523 2.649509 9.833378 9.097426
α-SMA 5.27888 4.027409 2.37067 1.848955
Slug 3.376403 2.962488 1.422036 0.659522
Snail 2.064503 2.359432 2.745241 2.941692
 Twist1 −1.065424 −1.4102 1.543533 0.969468
 Twist2 − 1.493418 − 1.6265 2.778423 2.162327
ZEB1 1.949302 2.012616 2.478841 1.987502
 ZEB2 1.325055 1.536987 1.286106 0.96196
 ZO-1 −1.053172 1.168809 4.765156 4.477092
Stem cell related
 CD44 1.983674 1.908933 6.979291 6.502286
CXCR4 11.88424 6.338601 1.237284 1.165821
 ABCG2 −1.958694 −2.58677 1.357162 2.001303
 ALDH1A1 −4.519745 −3.31873 10.49759 10.74185
 EpCAM −1.988084 −1.49956 1.015211 4.758595
 CD90 −1.252799 −1.08908 0.732683 0.177706
 Nanog −1.023746 −1.06456 0.036569 0.044168
 SOX2 −1.850566 −2.22392 0.491689 0.956587
 SSEA4 −1.451824 −1.24891 1.488286 1.510724
 CD166 1.117535 1.219265 5.011018 5.161295
 BMI-1 1.800887 1.659949 3.508488 3.755616
  1. EMT and stem cell markers more than 2–fold changes were marked in bold