Fig. 1

Transcriptome analysis of the BEAS-2B and A549 cells following hypoxic stimuli for 24 h using next-generation sequencing. a Heat map of the hierarchical clustering shows a distinct separation of mRNA expression patterns of the cells cultured under hypoxic and normoxic conditions. b Levels of mRNA encoding fibronectin, vimentin, α-SMA, Slug, Snail, and ZEB1 were highly induced in cells cultured in hypoxic compared with normoxic conditions; whereas, E-cadherin decreased when the cells were exposed to hypoxic stimuli. c Among the stem cell markers, the expression of CXCR4 increased following hypoxic stimuli in both the BEAS-2B and A549 cells