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Table 4 Treatment and consequences of CIT requiring inpatient or outpatient care

From: Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice

  All Agents
(n = 27,913)
Number of CIT-Related Hospital Admissions, mean per patient-episode (95% CI) 0.03 (0.03–0.03)
 Characteristics of Admissions (i.e., per admission)
   LOS, days, mean (95% CI) 4.6 (4.4–5.0)
   Mortalitya, % (95% CI) 4.7 (2.8–6.6)
   Diagnoses, % (95% CI)
     CIT Only 7.7 (5.7–9.6)
     Bleeding Only 85.2 (82.5–87.6)
     CIT and Bleeding 7.1 (5.4–9.1)
   Cost ($), mean per admission (95% CI) 36,448 (32,332 - 41,331)
 Number of Hospital Days, mean per patient-episode (95% CI) 0.13 (0.12–0.14)
 Cost of Admissions ($), mean per patient-episode (95% CI) 1024 (881–1167)
Number of CIT-Related Ambulatory Encounters, mean per patient-episode (95% CI) 3.7 (3.7–3.8)
 Characteristics of Outpatient Encounters (i.e., per encounter)
  Setting of Care, % (95% CI)
    Physician Office 44.6 (44.3–44.9)
    Emergency Department 2.2 (2.1–2.3)
    Hospital Outpatient 40.7 (40.4–41.0)
    Labs 4.5 (4.4–4.6)
    Other 8.0 (7.8–8.1)
  Diagnoses, % (95% CI)
    CIT Only 16.2 (16.0–16.4)
    Bleeding Only 15.8 (15.6–16.0)
    CIT and Bleeding 0.4 (0.4–0.5)
    None of the Above 67.5 (67.2–67.8)
  Procedures, % (95% CI)
    Blood Product Transfusion
      Platelet 2.0 (1.9–2.1)
      Red Blood 3.1 (3.0–3.2)
      Stem Cell 0.2 (0.2–0.2)
      Whole Blood 0.0 (0.0–0.0)
      Other 0.4 (0.3–0.4)
    Coagulation Factor Transfusion 0.0 (0.0–0.0)
    Control of Bleeding 0.7 (0.6–0.7)
    Labs 64.1 (63.8–64.4)
  Pharmacotherapy, % (95% CI)
    Glucocorticosteroid 28.3 (28.0–28.6)
   Immunoglobulin 0.0 (0.0–0.0)
    Thrombopoietin Receptor Agonists
     Eltrombopag ---
     Romiplostim 0.0 (0.0–0.0)
  Cost ($), mean per encounter (95% CI)
    Physician Office 123 (121–125)
    Emergency Department 839 (779–918)
    Hospital Outpatient 504 (486–524)
    Labs 11 (11–11)
    Other 359 (337–383)
 Cost of Ambulatory Encounters ($), mean per patient-episode (95% CI) 1153 (1119 - 1187)
Characteristics of Outpatient Pharmacotherapy
  Number of Filled Prescriptions, mean per patient-episode (95% CI) 0.2 (0.2–0.2)
    Glucocorticosteroid, % (95% CI) 99.9 (99.8–100.0)
    Immunoglobulin, % (95% CI) 0.1 (0.0–0.1)
    Thrombopoietin Receptor Agonists, % (95% CI)
      Eltrombopag 0.0 (0.0–0.1)
      Romiplostim 0
    Cost ($), mean per prescription (95% CI)
     Glucocorticosteroid 10 (10–11)
     Immunoglobulin 7302 (6735 - 7869)
     Thrombopoietin Receptor Agonists
       Eltrombopag 5640 (5038 - 6242)
       Romiplostim 0
  Cost of Prescriptions ($), mean per patient-episode (95% CI) 3 (2–4)
Total Cost per Cycle ($), mean per patient-episode 2179 (2029 - 2329)
  1. aHospital mortality was based on data from the MarketScan Database only