Skip to main content

Table 2 Characteristics of patients in study population, by chemotherapy agenta

From: Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice

  All Agents Carboplatin Cisplatin Cyclophosphamide Fluorouracil Gemcitabine Oxaliplatin Vincristine
(n = 215,508) (n = 60,966) (n = 22,393) (n = 83,665) (n = 42,970) (n = 6617) (n = 33,822) (n = 14,610)
Patient
 Age (years), mean (SD) 57.3 (11.3) 59.7 (11.3) 57.6 (10.8) 54.7 (10.9) 58.1 (10.8) 63.3 (11.4) 57.6 (10.7) 59.1 (14.0)
 Female, % 69.5 72.8 40.1 89.0 46.9 51.2 42.5 42.5
 Chronic Comorbidities, %
  Cardiovascular Disease 16.4 21.4 21.4 9.6 18.5 28.4 19.1 20.7
   Cardiac Dysrhythmias 8.1 10.0 9.8 5.0 9.7 14.3 10.3 10.4
   Cerebrovascular Disease 3.0 4.8 4.2 1.5 2.5 5.1 2.4 3.5
   Ischemic Heart Disease 8.4 11.3 11.9 4.3 9.7 15.9 9.7 10.7
   Heart Failure 2.6 3.7 2.6 1.4 2.9 5.2 2.9 3.7
  Diabetes 14.7 15.8 14.0 11.7 18.0 25.7 18.2 16.5
  Liver Disease 7.7 7.0 6.8 3.7 14.4 19.1 16.7 6.0
  Lung Disease 15.5 23.9 26.1 9.0 11.1 18.6 10.8 11.3
  Osteoarthritis 10.0 11.5 10.4 9.4 8.9 14.4 8.4 12.2
  Renal Disease 3.7 4.6 2.9 2.4 4.6 10.8 4.5 6.4
 Nutritional Status
  Malnutrition 2.3 2.3 2.8 0.5 4.8 6.2 5.3 2.1
  Obesity 9.1 9.3 7.4 8.3 10.6 8.6 12.1 8.2
 History of Other Conditions/Events Prior to Chemotherapy Course, %
  Anemia 20.9 19.9 18.0 12.4 36.2 30.9 41.6 25.9
  Neutropenia 2.3 2.3 1.9 3.0 1.2 3.3 1.1 8.6
  Infection 60.7 59.8 61.9 60.9 61.8 61.5 63.1 61.2
  History of Chemotherapy 4.8 5.0 3.5 5.1 3.4 10.7 2.9 19.0
  History of Hospitalization for Any Reason 45.2 48.4 46.8 28.3 65.1 59.4 77.1 39.3
  History of Radiation Therapy 16.2 19.0 44.4 4.1 21.6 15.1 13.3 3.9
  Recent Surgery 35.2 33.6 26.8 38.0 36.0 30.0 40.6 23.1
 Proxies for Health Status
  Hospice, % 0.4 0.5 0.2 0.3 0.5 0.6 0.5 0.4
  SNF, % 1.5 2.2 1.2 0.6 1.8 3.7 1.8 2.1
  Pre-Chemotherapy Expenditures ($)
    Mean (SD) 48,669 (47,526) 48,179 (50,374) 50,328 (48,500) 40,918 (33,823) 57,176 (53,867) 65,571 (70,875) 62,275 (55,302) 47,412 (49,110)
 Proxies for Physical Function, %
  Use of Hospital Bed 0.5 0.8 0.5 0.2 0.6 1.0 0.6 0.4
  Use of Supplemental Oxygen 4.4 7.7 7.9 1.8 2.9 6.8 2.7 3.3
  Use of Walking Aid 2.5 3.3 2.6 1.4 2.8 5.0 2.9 3.1
  Use of Wheelchair 0.8 1.3 0.7 0.4 0.6 1.8 0.6 1.1
  1. aAgent-specific subgroups are not mutually exclusive