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Fig. 5 | BMC Cancer

Fig. 5

From: Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

Fig. 5

IL6 mRNA expression is up-regulated in aggressive bladder cancer patient tumor specimens, correlates with CAF marker ACTA2 expression, and is associated with poor prognosis. Boxplots of IL6 (a-c) and ATCA2 (d-f) mRNA expression with respect to tumor stage, grade or invasiveness for TCGA (a-b, d-e, g) and GSE13507 (c, f, h) bladder cancer data. Number of tissues in each group is shown in brackets. The difference between groups was analyzed by Mann-Whitney test. ****P < 0.0001. g. Spearman’s correlation between ACTA2 and IL6 gene expression (r = 0.4543; ****P < 0.0001). h. Kaplan-Meier cancer specific survival curves according to lower versus higher half of ACTA2/IL6 mRNA co-expression level in bladder cancer patients (HR = 2.738; *P = 0.0471). Non-muscle invasive bladder cancer (NMIBC); muscle invasive bladder cancer (MIBC)

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