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Table 4 Mutations in CSF cell samples detected with different pipelines

From: Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases

Patients CFS cell Mutation sites/ (DNA input)
cHOPE OncoAim ddCAP ddCAP on Tissue
#1 EGFR L747_E749del NA NA NA
(8 ng)
#2 No mutation NA No mutation NA
(11 ng) (20 ng)
#3 No mutation NA NA NA
(14 ng)
#4 EGFR E746_A750del; TP53 R158L NA TP53 R158L NA
(9 ng) (30 ng)
#5 ALK G689R; EGFR L858R
(20 ng)
NA NA EGFR L858R
(50 ng)
#6 EGFR E746Valfs, P753Rfs
(20 ng)
EGFR E746_P753 > VS
(20 ng)
NA NA
#7 NA NA NA EGFR L858R
(50 ng)
#8 NA NA No mutation NA
(7 ng)
#9 TP53 W53 NA NA TP53 W53
(5 ng) (50 ng)
#10 NA NA EGFR L858R NA
(30 ng)
#11 EGFR L858R; TP53 D228Valfs EGFR L858R NA NA
(8 ng) (20 ng)
#12 TP53 V272 M; EGFR E746_A750del NA NA TP53 V272 M;
(10 ng) (50 ng)
#19 NA NA NA EGFR E746_A750del
(50 ng)
  1. NA not available