Table 4 Mutations in CSF cell samples detected with different pipelines
Patients | CFS cell Mutation sites/ (DNA input) | |||
|---|---|---|---|---|
cHOPE | OncoAim | ddCAP | ddCAP on Tissue | |
#1 | EGFR L747_E749del | NA | NA | NA |
(8 ng) | ||||
#2 | No mutation | NA | No mutation | NA |
(11 ng) | (20 ng) | |||
#3 | No mutation | NA | NA | NA |
(14 ng) | ||||
#4 | EGFR E746_A750del; TP53 R158L | NA | TP53 R158L | NA |
(9 ng) | (30 ng) | |||
#5 | ALK G689R; EGFR L858R (20 ng) | NA | NA | EGFR L858R (50 ng) |
#6 | EGFR E746Valfs, P753Rfs (20 ng) | EGFR E746_P753 > VS (20 ng) | NA | NA |
#7 | NA | NA | NA | EGFR L858R |
(50 ng) | ||||
#8 | NA | NA | No mutation | NA |
(7 ng) | ||||
#9 | TP53 W53 | NA | NA | TP53 W53 |
(5 ng) | (50 ng) | |||
#10 | NA | NA | EGFR L858R | NA |
(30 ng) | ||||
#11 | EGFR L858R; TP53 D228Valfs | EGFR L858R | NA | NA |
(8 ng) | (20 ng) | |||
#12 | TP53 V272 M; EGFR E746_A750del | NA | NA | TP53 V272 M; |
(10 ng) | (50 ng) | |||
#19 | NA | NA | NA | EGFR E746_A750del |
(50 ng) | ||||