Fig. 4

Effects of PAHs on HPV-infected cell motility. MCF7, C33A and SiHa cells were exposed to 1 μM of PAHs for three days. Changes of their migration capacity was assessed by wound-healing assay and represented by cell migration index (a). This index was calculated as the cell migrated area of experimental groups divided by the control groups in each cell line. Data are presented as the mean ± SEM from three independent experiments. Significant level: *p < 0.05, **p < 0.01, ***p < 0.001. Microscopic image captured at time point 0 h and 48 h are shown. Wounded area are indicated by dotted lines (b). BaP, benzo[a]pyrene; DBA, dibenz[a,h]anthracene; IDP, indeno[1,2,3-cd]pyrene; PR, pyrene