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Table 4 Variant information for the significant genotypes in the multivariable mixture cure and Cox proportional hazards regression models

From: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Genomic location rs number (genotypea) MAFb Statistical modelc Type of variant (gene)d DNA binding evidencee
22:17793969 rs5749032 (GG) 40% Mixture cure Intergenic ND
20:16189263 rs2327990 (TT) 11% Cox proportional hazards Intergenic Less likely to affect binding
3:134513356 rs11918092 (CC) 8% Cox proportional hazards Intronic (EPHB1) Minimal binding evidence
3:134515336 rs3732568 (AA) 8% Cox proportional hazards Intronic (EPHB1) Minimal binding evidence
3:59930672 rs2366964 (CC) 8% Cox proportional hazards Intronic (FHIT) ND
2:6769988 rs1563948 (AA) 11% Cox proportional hazards Intronic (MIR7515) Minimal binding evidence
2:6773920 rs11694697 (TT) 11% Cox proportional hazards Intronic (MIR7515) ND
2:6777992 rs11692570 (TT) 11% Cox proportional hazards Intronic (MIR7515) Minimal binding evidence
2:6779277 rs2219613 (TT) 11% Cox proportional hazards Intronic (MIR7515) Minimal binding evidence
6:91187510 rs1145724 (GG) 9% Cox proportional hazards Intergenic Minimal binding evidence
  1. a Risk increasing/decreasing genotype, b MAF calculated from patient cohort analyzed. Values comparable to CEU population based on 1000 Genomes Project Phase 3 28 data obtained through the Ensembl database (http://grch37.ensembl.org/), c Statistical model identifying the association, d based on Ensembl database [25], e based on RegulomeDB database [26]. ND: no data
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BMC Cancer

ISSN: 1471-2407

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