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Table 3 Genotypes significantly associated with time-to-metastasis after adjusting for significant baseline characteristics identified in the Cox proportional hazards regression model

From: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Genomic location

rs number (genotypes a vs. b)

Genotype freq.

Univariable

Multivariablea

HR

95% CI

p-value

HR

95% CI

p-value

20:16189263

rs2327990 (TT vs. CC + CT)

1.3%

21.97

8.42–57.33

2.74 × 10− 10

22.58

8.32–61.31

9.59 × 10− 10

3:134513356

rs11918092 (CC vs. AA + AC)

0.5%

216.98

35.64–1321.13

5.32 × 10− 9

535.33

63.20–4534.30

8.23 × 10− 9

3:134515336

rs3732568 (AA vs. CC + CA)

0.5%

216.98

35.64–1321.13

5.32 × 10− 9

535.33

63.20–4534.30

8.23 × 10− 9

3:59930672

rs2366964 (CC vs. TT + TC)

0.8%

41.19

11.81–143.66

5.40 × 10−9

56.53

14.98–213.26

2.59 × 10− 9

2:6769988

rs1563948 (AA vs. GG + GA)

0.8%

34.43

10.35–114.58

7.97 × 10−9

33.97

9.57–120.54

4.87 × 10− 8

2:6773920

rs11694697 (TT vs. CC + CT)

0.8%

34.43

10.35–114.58

7.97 × 10−9

33.97

9.57–120.54

4.87 × 10− 8

2:6777992

rs11692570 (TT vs. CC + CT)

0.8%

34.43

10.35–114.58

7.97 × 10−9

33.97

9.57–120.54

4.87 × 10− 8

2:6779277

rs2219613 (TT vs. CC + CT)

0.8%

34.43

10.35–114.58

7.97 × 10−9

33.97

9.57–120.54

4.87 × 10−8

6:91187510

rs1145724 (GG vs. AA + AG)

0.8%

30.76

9.27–102.03

2.14 × 10−8

36.43

10.21–129.93

3.00 × 10−8

  1. aAdjusted for tumor location, 5-fluorouracil treatment status, BRAF V600E somatic mutation status, and tumor stage. Each SNP was analyzed separately adjusting for these factors. Patients with missing data were excluded, resulting in the inclusion of 349 stage I-III patients with MSI-L/MSS tumors
  2. LD calculations indicated that rs11918092 and rs3732568 are in high pairwise LD (r2 = 0.96). In addition, rs1563948, rs11694697, rs11692570, and rs2219613 are all highly linked to each other (0.94 ≤ r2 ≤ 1)
  3. The SNPs listed yielded similar risk estimates under the univariable and multivariable analyses. Consequently, all of the SNPs identified in this study could be considered independent prognostic factors for time-to-metastasis in colorectal cancer if the results are replicated using independent cohort data
  4. Genotype freq. frequency of genotype a calculated from the patient cohort, HR hazard ratio comparing metastasis rate in subgroup a with that in subgroup b, CI confidence interval