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Table 3 Genotypes significantly associated with time-to-metastasis after adjusting for significant baseline characteristics identified in the Cox proportional hazards regression model

From: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Genomic location rs number (genotypes a vs. b) Genotype freq. Univariable Multivariablea
HR 95% CI p-value HR 95% CI p-value
20:16189263 rs2327990 (TT vs. CC + CT) 1.3% 21.97 8.42–57.33 2.74 × 10− 10 22.58 8.32–61.31 9.59 × 10− 10
3:134513356 rs11918092 (CC vs. AA + AC) 0.5% 216.98 35.64–1321.13 5.32 × 10− 9 535.33 63.20–4534.30 8.23 × 10− 9
3:134515336 rs3732568 (AA vs. CC + CA) 0.5% 216.98 35.64–1321.13 5.32 × 10− 9 535.33 63.20–4534.30 8.23 × 10− 9
3:59930672 rs2366964 (CC vs. TT + TC) 0.8% 41.19 11.81–143.66 5.40 × 10−9 56.53 14.98–213.26 2.59 × 10− 9
2:6769988 rs1563948 (AA vs. GG + GA) 0.8% 34.43 10.35–114.58 7.97 × 10−9 33.97 9.57–120.54 4.87 × 10− 8
2:6773920 rs11694697 (TT vs. CC + CT) 0.8% 34.43 10.35–114.58 7.97 × 10−9 33.97 9.57–120.54 4.87 × 10− 8
2:6777992 rs11692570 (TT vs. CC + CT) 0.8% 34.43 10.35–114.58 7.97 × 10−9 33.97 9.57–120.54 4.87 × 10− 8
2:6779277 rs2219613 (TT vs. CC + CT) 0.8% 34.43 10.35–114.58 7.97 × 10−9 33.97 9.57–120.54 4.87 × 10−8
6:91187510 rs1145724 (GG vs. AA + AG) 0.8% 30.76 9.27–102.03 2.14 × 10−8 36.43 10.21–129.93 3.00 × 10−8
  1. aAdjusted for tumor location, 5-fluorouracil treatment status, BRAF V600E somatic mutation status, and tumor stage. Each SNP was analyzed separately adjusting for these factors. Patients with missing data were excluded, resulting in the inclusion of 349 stage I-III patients with MSI-L/MSS tumors
  2. LD calculations indicated that rs11918092 and rs3732568 are in high pairwise LD (r2 = 0.96). In addition, rs1563948, rs11694697, rs11692570, and rs2219613 are all highly linked to each other (0.94 ≤ r2 ≤ 1)
  3. The SNPs listed yielded similar risk estimates under the univariable and multivariable analyses. Consequently, all of the SNPs identified in this study could be considered independent prognostic factors for time-to-metastasis in colorectal cancer if the results are replicated using independent cohort data
  4. Genotype freq. frequency of genotype a calculated from the patient cohort, HR hazard ratio comparing metastasis rate in subgroup a with that in subgroup b, CI confidence interval