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Table 3 Univariable Cox regression analysis

From: Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort

Parameter Overall survival Recurrence-free survival
  HR (95% CI) p-value HR (95% CI) p-value
Age (years at diagnosis)
 < 73 1 0.001 1 0.009
 ≥73 2.533 (1.466–4.377)   2.194 (1.216–3.958)  
Gender
 Male 1 0.462 1 0.634
 Female 0.839 (0.524–1.341)   0.881 (0.523–1.484)  
T-stage
 T3 1 0.003 1 0.002
 T4 2.68 (1.409–5.128)   2.982 (1.503–5.915)  
Malignancy grade
 Medium/Low 1 0.536 1 0.636
 Higha 1.159 (0.726–1.852)   1.134 (0.675–1.906)  
Localisation
 Right 1 0.792 1 0.150
 Left 1.084 (0.594–1.981)   1.576 (0.848–2.927)  
Tumour perforation
 No 1 0.001 1 0.005
 Yes 5.332 (1.924–14.776)   5.644 (1.708–18.645)  
Lymph nodes
 < 12 nodes 1 0.440 1 0.220
 ≥12 nodes 1.203 (0.753–1.922)   1.386 (0.823–2.334)  
Perineural invasion
 No 1 0.630 1 0.873
 Yes 1.417 (0.343–5.857)   0.850 (0.117–6.203)  
Vascular invasion
 No 1 0.878 1 0.756
 Yes 0.922 (0.332–2.566)   0.830 (0.256–2.690)  
PD-L1
 Low 1 0.748 1 0.258
 High 1.104 (0.604–2.016)   1.429 (0.769–2.653)  
  1. Univariable Cox regression analysis regarding overall survival and recurrence-free survival for the sub-cohort of patients with MSI tumours (N = 172). Statistically significant p-values are highlighted in bold
  2. aIncluding mucinous adenocarcinomas and signet-ring cell carcinomas
  3. MSI microsatellite instability