Table 3 Univariable Cox regression analysis
Parameter | Overall survival | Recurrence-free survival | ||
|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |
Age (years at diagnosis) | ||||
< 73 | 1 | 0.001 | 1 | 0.009 |
≥73 | 2.533 (1.466–4.377) | 2.194 (1.216–3.958) | ||
Gender | ||||
Male | 1 | 0.462 | 1 | 0.634 |
Female | 0.839 (0.524–1.341) | 0.881 (0.523–1.484) | ||
T-stage | ||||
T3 | 1 | 0.003 | 1 | 0.002 |
T4 | 2.68 (1.409–5.128) | 2.982 (1.503–5.915) | ||
Malignancy grade | ||||
Medium/Low | 1 | 0.536 | 1 | 0.636 |
Higha | 1.159 (0.726–1.852) | 1.134 (0.675–1.906) | ||
Localisation | ||||
Right | 1 | 0.792 | 1 | 0.150 |
Left | 1.084 (0.594–1.981) | 1.576 (0.848–2.927) | ||
Tumour perforation | ||||
No | 1 | 0.001 | 1 | 0.005 |
Yes | 5.332 (1.924–14.776) | 5.644 (1.708–18.645) | ||
Lymph nodes | ||||
< 12 nodes | 1 | 0.440 | 1 | 0.220 |
≥12 nodes | 1.203 (0.753–1.922) | 1.386 (0.823–2.334) | ||
Perineural invasion | ||||
No | 1 | 0.630 | 1 | 0.873 |
Yes | 1.417 (0.343–5.857) | 0.850 (0.117–6.203) | ||
Vascular invasion | ||||
No | 1 | 0.878 | 1 | 0.756 |
Yes | 0.922 (0.332–2.566) | 0.830 (0.256–2.690) | ||
PD-L1 | ||||
Low | 1 | 0.748 | 1 | 0.258 |
High | 1.104 (0.604–2.016) | 1.429 (0.769–2.653) | ||