Table 1 Clinico-pathological characteristics and association to PD-L1 (cut-off 5%)
Number | PD-L1 | |||
|---|---|---|---|---|
(N = 572) (%) | Low (%) | High (%) | p-value | |
Age (years at diagnosis) | ||||
Median | 72 | |||
Range | 29–95 | |||
≥ 73 | 267 (47) | 253 (47) | 14 (40) | 0.414 |
< 73 | 305 (53) | 284 (53) | 21 (60) | |
Gender | ||||
Male | 283 (49) | 272 (51) | 11 (31) | 0.028 |
Female | 289 (51) | 265 (49) | 24 (69) | |
T-stage | ||||
pT3 | 500 (87) | 472 (88) | 28 (80) | 0.172 |
pT4 | 72 (13) | 65 (12) | 7 (20) | |
Histology (WHO) | ||||
Adenocarcinoma NOS | 515 (90) | 481 (90) | 34 (97) | 0.348 |
Mucinous adenocarcinoma | 55 (10) | 54 (10) | 1 (3) | |
Signet-ring cell carcinoma | 2 (0) | 2 (1) | 0 (0) | |
Malignancy grade | ||||
Medium + low | 450 (79) | 436 (81) | 14 (40) | < 0.001 |
Higha | 122 (21) | 101 (19) | 21 (60) | |
Localisation | ||||
Right | 273 (48) | 242 (45) | 31 (89) | < 0.001 |
Left | 299 (52) | 295 (55) | 4 (11) | |
Tumour perforation | ||||
Yes | 530 (93) | 499 (97) | 31 (94) | 0.313 |
No | 17 (3) | 15 (3) | 2 (6) | |
Unknown | 25 (4) | |||
Lymph nodes | ||||
Median | 10 | |||
Range | 0–41 | |||
< 12 nodes | 351 (61) | 329 (61) | 22 (63) | 0.851 |
≥ 12 nodes | 221 (39) | 208 (39) | 13 (37) | |
Perineural invasion | ||||
Yes | 26 (5) | 25 (7) | 1 (4) | 0.635 |
No | 359 (63) | 337 (93) | 22 (96) | |
Not assessed | 187 (32) | |||
Vascular invasion | ||||
Yes | 43 (7) | 38 (9) | 5 (22) | 0.054 |
No | 386 (68) | 368 (91) | 18 (78) | |
Not assessed | 143 (25) | |||
Mismatch repair status | ||||
MSS | 400 (70) | 396 (74) | 4 (11) | < 0.001 |
MSI | 172 (30) | 141 (26) | 31 (89) | |