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Table 1 Clinico-pathological characteristics and association to PD-L1 (cut-off 5%)

From: Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort

  Number PD-L1
  (N = 572) (%) Low (%) High (%) p-value
Age (years at diagnosis)
 Median 72    
 Range 29–95    
  ≥ 73 267 (47) 253 (47) 14 (40) 0.414
  < 73 305 (53) 284 (53) 21 (60)  
Gender
 Male 283 (49) 272 (51) 11 (31) 0.028
 Female 289 (51) 265 (49) 24 (69)  
T-stage
 pT3 500 (87) 472 (88) 28 (80) 0.172
 pT4 72 (13) 65 (12) 7 (20)  
Histology (WHO)
 Adenocarcinoma NOS 515 (90) 481 (90) 34 (97) 0.348
 Mucinous adenocarcinoma 55 (10) 54 (10) 1 (3)  
 Signet-ring cell carcinoma 2 (0) 2 (1) 0 (0)  
Malignancy grade
 Medium + low 450 (79) 436 (81) 14 (40) < 0.001
 Higha 122 (21) 101 (19) 21 (60)  
Localisation
 Right 273 (48) 242 (45) 31 (89) < 0.001
 Left 299 (52) 295 (55) 4 (11)  
Tumour perforation
 Yes 530 (93) 499 (97) 31 (94) 0.313
 No 17 (3) 15 (3) 2 (6)  
 Unknown 25 (4)    
Lymph nodes
 Median 10    
 Range 0–41    
  < 12 nodes 351 (61) 329 (61) 22 (63) 0.851
  ≥ 12 nodes 221 (39) 208 (39) 13 (37)  
Perineural invasion
 Yes 26 (5) 25 (7) 1 (4) 0.635
 No 359 (63) 337 (93) 22 (96)  
 Not assessed 187 (32)    
Vascular invasion
 Yes 43 (7) 38 (9) 5 (22) 0.054
 No 386 (68) 368 (91) 18 (78)  
 Not assessed 143 (25)    
Mismatch repair status
 MSS 400 (70) 396 (74) 4 (11) < 0.001
 MSI 172 (30) 141 (26) 31 (89)  
  1. Abbreviations: MSI microsatellite instability, MSS microsatellite stable, NOS not otherwise specified
  2. aIncluding mucinous adenocarcinomas and signet-ring cell carcinomas
  3. P-values are obtained using chi2-test. Statistically significant p-values are highlighted in bold