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Table 4 Intracranial and intraspinal tumours among children aged 0–14 years resident in Great Britain, 1971–2010. Numbers of registrations (N) and age-standardised rates (world standard population) (ASR) in successive quinquennia of diagnosis, by ICCC-3 category and ICD-O-3 behaviour code

From: Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study

ICCC-3 1971–1975 1976–1980 1981–1985 1986–1990 1991–1995 1996–2000 2001–2005 2006–2010
N ASR N ASR N ASR N ASR N ASR N ASR N ASR N ASR
IIIa.1 Ependymoma 181 2.9 164 3.0 131 2.6 121 2.4 127 2.4 134 2.6 139 2.8 152 3.0
IIIa.2 Choroid plexus tumours 13 0.2 24 0.5 31 0.7 28 0.6 43 0.9 48 1.0 54 1.2 57 1.2
IIIb Astrocytoma 563 8.7 611 10.3 518 9.7 606 11.8 780 14.4 786 14.5 842 16.1 865 16.8
  Pilocytic, optic nerve 12 0.2 16 0.3 10 0.2 15 0.3 25 0.5 22 0.4 31 0.7 29 0.6
  Pilocytic, other sites 173 2.7 222 3.7 162 3.0 181 3.5 256 4.7 360 6.6 382 7.2 418 8.0
  Other non-malignant behaviour 2 < 0.05 5 0.1 3 < 0.05 5 0.1 13 0.2 23 0.4 21 0.4 21 0.4
  Malignant behaviour, optic nerve 43 0.7 49 0.9 46 0.9 52 1.1 71 1.4 102 2.0 113 2.3 139 2.8
  Malignant behaviour, other sites 333 5.1 319 5.3 297 5.5 353 6.8 415 7.6 279 5.1 295 5.5 258 5.0
IIIc.1 Medulloblastoma 316 5.0 306 5.3 277 5.4 237 4.6 256 4.8 254 4.7 272 5.3 252 4.9
IIIc.2 Embryonal CNS tumour NOS 2 < 0.05 9 0.2 40 0.8 70 1.4 86 1.7 75 1.5 50 1.0 59 1.2
IIIc.3 Medulloepithelioma/neuroepithelioma 1 < 0.05 2 < 0.05 0 2 < 0.05 5 0.1 2 < 0.05 2 < 0.05 1 < 0.05
IIIc.4 Atypical teratoid/rhabdoid tumour 0 0 0 2 < 0.05 2 < 0.05 22 0.5 32 0.7 49 1.0
IIId.1 Oligodendroglioma 34 0.5 21 0.3 33 0.6 24 0.5 19 0.3 13 0.2 14 0.3 20 0.4
IIId.2 Mixed and unspecified gliomas 225 3.4 227 3.8 179 3.4 185 3.5 162 3.0 174 3.2 169 3.2 171 3.3
IIId.3 Other neuroepithelial tumours 3 0.1 0 2 < 0.05 5 0.1 4 0.1 1 < 0.05 6 0.1 17 0.3
IIIe.1 Pituitary adenoma 5 0.1 10 0.1 6 0.1 6 0.1 10 0.2 10 0.2 30 0.5 37 0.6
IIIe.2 Craniopharyngioma 70 1.1 91 1.5 65 1.2 77 1.4 105 1.9 98 1.7 91 1.6 100 1.9
IIIe.3 Pineal parenchymal tumours 25 0.4 31 0.6 22 0.3 17 0.3 16 0.3 23 0.4 24 0.5 22 0.4
IIIe.4 Mixed glial-neuronal tumours 5 0.1 6 0.1 10 0.2 15 0.3 48 0.9 100 1.8 104 1.9 119 2.2
IIIe.5 Meningioma 26 0.4 21 0.3 21 0.3 15 0.3 31 0.5 17 0.3 22 0.4 28 0.5
IIIf Unspecified tumours 153 2.3 61 1.1 83 1.6 86 1.7 104 1.9 67 1.3 97 1.9 99 1.9
Xa Germ cell tumours 33 0.5 50 0.8 67 1.2 56 1.1 82 1.5 85 1.5 83 1.5 87 1.6
ICD-O-3 behaviour  
 0, 1 Non-malignant 475 7.3 481 8.2 407 7.5 429 8.3 623 11.5 746 13.6 823 15.5 903 17.2
 3 Malignant 1180 18.5 1153 19.8 1078 20.5 1123 21.8 1257 23.4 1163 21.8 1208 23.5 1232 24.1
Total 1655 25.7 1634 28.0 1485 28.1 1552 30.1 1880 34.9 1909 35.4 2031 38.9 2135 41.3
  1. Source: National Registry of Childhood Tumours