Table 4 Intracranial and intraspinal tumours among children aged 0–14 years resident in Great Britain, 1971–2010. Numbers of registrations (N) and age-standardised rates (world standard population) (ASR) in successive quinquennia of diagnosis, by ICCC-3 category and ICD-O-3 behaviour code
ICCC-3 | 1971–1975 | 1976–1980 | 1981–1985 | 1986–1990 | 1991–1995 | 1996–2000 | 2001–2005 | 2006–2010 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | ASR | N | ASR | N | ASR | N | ASR | N | ASR | N | ASR | N | ASR | N | ASR | ||
IIIa.1 | Ependymoma | 181 | 2.9 | 164 | 3.0 | 131 | 2.6 | 121 | 2.4 | 127 | 2.4 | 134 | 2.6 | 139 | 2.8 | 152 | 3.0 |
IIIa.2 | Choroid plexus tumours | 13 | 0.2 | 24 | 0.5 | 31 | 0.7 | 28 | 0.6 | 43 | 0.9 | 48 | 1.0 | 54 | 1.2 | 57 | 1.2 |
IIIb | Astrocytoma | 563 | 8.7 | 611 | 10.3 | 518 | 9.7 | 606 | 11.8 | 780 | 14.4 | 786 | 14.5 | 842 | 16.1 | 865 | 16.8 |
| Â | Pilocytic, optic nerve | 12 | 0.2 | 16 | 0.3 | 10 | 0.2 | 15 | 0.3 | 25 | 0.5 | 22 | 0.4 | 31 | 0.7 | 29 | 0.6 |
| Â | Pilocytic, other sites | 173 | 2.7 | 222 | 3.7 | 162 | 3.0 | 181 | 3.5 | 256 | 4.7 | 360 | 6.6 | 382 | 7.2 | 418 | 8.0 |
|  | Other non-malignant behaviour | 2 | < 0.05 | 5 | 0.1 | 3 | < 0.05 | 5 | 0.1 | 13 | 0.2 | 23 | 0.4 | 21 | 0.4 | 21 | 0.4 |
| Â | Malignant behaviour, optic nerve | 43 | 0.7 | 49 | 0.9 | 46 | 0.9 | 52 | 1.1 | 71 | 1.4 | 102 | 2.0 | 113 | 2.3 | 139 | 2.8 |
| Â | Malignant behaviour, other sites | 333 | 5.1 | 319 | 5.3 | 297 | 5.5 | 353 | 6.8 | 415 | 7.6 | 279 | 5.1 | 295 | 5.5 | 258 | 5.0 |
IIIc.1 | Medulloblastoma | 316 | 5.0 | 306 | 5.3 | 277 | 5.4 | 237 | 4.6 | 256 | 4.8 | 254 | 4.7 | 272 | 5.3 | 252 | 4.9 |
IIIc.2 | Embryonal CNS tumour NOS | 2 | < 0.05 | 9 | 0.2 | 40 | 0.8 | 70 | 1.4 | 86 | 1.7 | 75 | 1.5 | 50 | 1.0 | 59 | 1.2 |
IIIc.3 | Medulloepithelioma/neuroepithelioma | 1 | < 0.05 | 2 | < 0.05 | 0 | – | 2 | < 0.05 | 5 | 0.1 | 2 | < 0.05 | 2 | < 0.05 | 1 | < 0.05 |
IIIc.4 | Atypical teratoid/rhabdoid tumour | 0 | – | 0 | – | 0 | – | 2 | < 0.05 | 2 | < 0.05 | 22 | 0.5 | 32 | 0.7 | 49 | 1.0 |
IIId.1 | Oligodendroglioma | 34 | 0.5 | 21 | 0.3 | 33 | 0.6 | 24 | 0.5 | 19 | 0.3 | 13 | 0.2 | 14 | 0.3 | 20 | 0.4 |
IIId.2 | Mixed and unspecified gliomas | 225 | 3.4 | 227 | 3.8 | 179 | 3.4 | 185 | 3.5 | 162 | 3.0 | 174 | 3.2 | 169 | 3.2 | 171 | 3.3 |
IIId.3 | Other neuroepithelial tumours | 3 | 0.1 | 0 | – | 2 | < 0.05 | 5 | 0.1 | 4 | 0.1 | 1 | < 0.05 | 6 | 0.1 | 17 | 0.3 |
IIIe.1 | Pituitary adenoma | 5 | 0.1 | 10 | 0.1 | 6 | 0.1 | 6 | 0.1 | 10 | 0.2 | 10 | 0.2 | 30 | 0.5 | 37 | 0.6 |
IIIe.2 | Craniopharyngioma | 70 | 1.1 | 91 | 1.5 | 65 | 1.2 | 77 | 1.4 | 105 | 1.9 | 98 | 1.7 | 91 | 1.6 | 100 | 1.9 |
IIIe.3 | Pineal parenchymal tumours | 25 | 0.4 | 31 | 0.6 | 22 | 0.3 | 17 | 0.3 | 16 | 0.3 | 23 | 0.4 | 24 | 0.5 | 22 | 0.4 |
IIIe.4 | Mixed glial-neuronal tumours | 5 | 0.1 | 6 | 0.1 | 10 | 0.2 | 15 | 0.3 | 48 | 0.9 | 100 | 1.8 | 104 | 1.9 | 119 | 2.2 |
IIIe.5 | Meningioma | 26 | 0.4 | 21 | 0.3 | 21 | 0.3 | 15 | 0.3 | 31 | 0.5 | 17 | 0.3 | 22 | 0.4 | 28 | 0.5 |
IIIf | Unspecified tumours | 153 | 2.3 | 61 | 1.1 | 83 | 1.6 | 86 | 1.7 | 104 | 1.9 | 67 | 1.3 | 97 | 1.9 | 99 | 1.9 |
Xa | Germ cell tumours | 33 | 0.5 | 50 | 0.8 | 67 | 1.2 | 56 | 1.1 | 82 | 1.5 | 85 | 1.5 | 83 | 1.5 | 87 | 1.6 |
ICD-O-3 behaviour | Â | ||||||||||||||||
 0, 1 | Non-malignant | 475 | 7.3 | 481 | 8.2 | 407 | 7.5 | 429 | 8.3 | 623 | 11.5 | 746 | 13.6 | 823 | 15.5 | 903 | 17.2 |
 3 | Malignant | 1180 | 18.5 | 1153 | 19.8 | 1078 | 20.5 | 1123 | 21.8 | 1257 | 23.4 | 1163 | 21.8 | 1208 | 23.5 | 1232 | 24.1 |
Total | 1655 | 25.7 | 1634 | 28.0 | 1485 | 28.1 | 1552 | 30.1 | 1880 | 34.9 | 1909 | 35.4 | 2031 | 38.9 | 2135 | 41.3 | |