Table 3 Intracranial and intraspinal tumours among children aged 0–14 years resident in Great Britain, 2001–2010. Numbers of registrations (N), % microscopically verified (MV), rates per million children by age group, age standardised rates (world standard population) (ASR) by sex
| Â | Â | Â | Â | Â | Â | Â | Â | Â | ASR | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
ICCC-3 |  |  | N | %MV | 0 | 1–4 | 5–9 | 10–14 | M | F | Total |
IIIa.1 | Ependymoma | 291 | 96.9 | 2.6 | 4.4 | 2.4 | 1.9 | 3.1 | 2.7 | 2.9 | |
| Â | Â | Unspecified | 149 | 96.0 | 1.4 | 2.2 | 1.4 | 0.9 | 1.6 | 1.4 | 1.5 |
| Â | Â | Anaplastic/ependymoblastoma | 109 | 100 | 1.1 | 2.1 | 0.8 | 0.4 | 1.2 | 1.0 | 1.1 |
|  |  | Papillary | 3 | 66.7 | – | < 0.05 | – | 0.1 | < 0.05 | < 0.05 | < 0.05 |
|  |  | Myxopapillary | 28 | 100 | – | 0.1 | 0.2 | 0.5 | 0.3 | 0.2 | 0.2 |
|  |  | Subependymoma | 2 | 0 | – | – | < 0.05 | < 0.05 | – | < 0.05 | < 0.05 |
IIIa.2 | Choroid plexus tumours | 111 | 99.1 | 6.4 | 1.5 | 0.4 | 0.3 | 1.3 | 1.1 | 1.2 | |
| Â | Â | Papilloma | 62 | 100 | 3.4 | 0.8 | 0.2 | 0.2 | 0.8 | 0.5 | 0.7 |
|  |  | Atypical papilloma | 13 | 100 | 1.0 | 0.1 | 0.1 | – | 0.1 | 0.2 | 0.1 |
| Â | Â | Carcinoma | 36 | 97.2 | 2.0 | 0.6 | 0.1 | 0.1 | 0.4 | 0.4 | 0.4 |
IIIb | Astrocytoma | 1707 | 81.7 | 11.1 | 19.4 | 16.5 | 14.7 | 16.4 | 16.5 | 16.5 | |
| Â | Â | Unspecified (optic nerve) | 249 | 7.6 | 1.7 | 4.5 | 2.3 | 1.0 | 2.3 | 2.8 | 2.5 |
| Â | Â | Unspecified (other sites) | 222 | 82.9 | 1.3 | 2.5 | 2.3 | 1.9 | 2.3 | 2.0 | 2.1 |
| Â | Â | Pilocytic | 860 | 97.0 | 2.6 | 9.7 | 8.5 | 7.9 | 8.0 | 8.4 | 8.2 |
| Â | Â | Subependymal giant cell | 42 | 78.6 | 0.4 | 0.2 | 0.4 | 0.5 | 0.5 | 0.3 | 0.4 |
|  |  | Gliofibroma | 1 | 100 | – | – | – | < 0.05 | – | < 0.05 | < 0.05 |
|  |  | Protoplasmic | 1 | 100 | – | < 0.05 | – | – | – | < 0.05 | < 0.05 |
|  |  | Gemistocytic | 3 | 100 | – | – | – | 0.1 | < 0.05 | – | < 0.05 |
|  |  | Fibrillary | 29 | 96.6 | – | 0.4 | 0.1 | 0.3 | 0.3 | 0.2 | 0.3 |
|  |  | Pleomorphic xanthoastrocytoma | 22 | 100 | – | 0.1 | 0.1 | 0.4 | 0.2 | 0.2 | 0.2 |
| Â | Â | Pilomyxoid | 38 | 97.4 | 1.6 | 0.5 | 0.1 | 0.2 | 0.4 | 0.4 | 0.4 |
| Â | Â | Anaplastic | 93 | 97.8 | 1.0 | 0.6 | 1.0 | 0.9 | 0.9 | 0.8 | 0.9 |
| Â | Â | Glioblastoma | 147 | 97.3 | 2.6 | 0.8 | 1.7 | 1.3 | 1.5 | 1.3 | 1.4 |
IIIc.1 | Medulloblastoma | 522 | 98.5 | 3.3 | 5.9 | 6.1 | 3.6 | 6.5 | 3.5 | 5.1 | |
| Â | Â | Unspecified | 394 | 98.0 | 2.0 | 3.9 | 5.0 | 2.8 | 5.0 | 2.5 | 3.8 |
| Â | Â | Desmoplastic/nodular/extensive nodularity | 84 | 100 | 1.1 | 1.5 | 0.5 | 0.5 | 1.0 | 0.7 | 0.9 |
|  |  | Medullomyoblastoma | 6 | 100 | – | 0.1 | 0.1 | – | 0.1 | – | 0.1 |
| Â | Â | Large cell/anaplastic | 38 | 100 | 0.1 | 0.4 | 0.5 | 0.2 | 0.4 | 0.3 | 0.4 |
IIIc.2 | Embryonal CNS tumour NOS | 111 | 95.5 | 2.7 | 1.6 | 0.7 | 0.7 | 1.0 | 1.2 | 1.1 | |
IIIc.3 | Medulloepithelioma/neuroepithelioma | 3 | 100 | – | < 0.05 | 0.1 | – | < 0.05 | < 0.05 | < 0.05 | |
IIIc.4 | Atypical teratoid/rhabdoid tumour | 81 | 96.3 | 3.3 | 1.7 | 0.2 | 0.2 | 0.9 | 0.9 | 0.9 | |
IIId.1 | Oligodendroglioma | 34 | 100 | – | 0.5 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | |
IIId.2 | Mixed and unspecified gliomas | 340 | 22.9 | 1.0 | 3.2 | 4.2 | 2.8 | 3.4 | 3.1 | 3.2 | |
| Â | Â | Unspecified | 318 | 17.6 | 1.0 | 3.0 | 4.1 | 2.4 | 3.2 | 2.9 | 3.0 |
|  |  | Mixed | 19 | 100 | – | 0.1 | 0.1 | 0.4 | 0.2 | 0.2 | 0.2 |
|  |  | Angiocentric glioma | 3 | 100 | – | < 0.05 | < 0.05 | < 0.05 | < 0.05 | < 0.05 | < 0.05 |
IIId.3 | Other neuroepithelial tumours | 23 | 82.6 | 0.1 | 0.1 | 0.2 | 0.3 | 0.2 | 0.2 | 0.2 | |
| Â | Â | Gliomatosis cerebri | 13 | 76.9 | 0.1 | 0.1 | 0.1 | 0.2 | 0.2 | 0.1 | 0.1 |
|  |  | Papillary tumour of the pineal region | 5 | 100 | – | – | 0.1 | 0.1 | < 0.05 | 0.1 | < 0.05 |
|  |  | Astroblastoma | 5 | 80.0 | – | 0.1 | < 0.05 | 0.1 | < 0.05 | 0.1 | < 0.05 |
IIIe.1 | Pituitary adenoma | 67 | 62.7 | – | 0.1 | 0.2 | 1.5 | 0.5 | 0.6 | 0.6 | |
IIIe.2 | Craniopharyngioma | 191 | 82.7 | 0.1 | 1.2 | 2.2 | 2.2 | 1.8 | 1.7 | 1.7 | |
IIIe.3 | Pineal parenchymal tumours | 46 | 97.8 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | |
|  |  | Pineocytoma | 4 | 100 | – | < 0.05 | 0.1 | < 0.05 | < 0.05 | < 0.05 | < 0.05 |
| Â | Â | Pineoblastoma incl. PTID | 42 | 97.6 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 |
IIIe.4 | Mixed glial-neuronal tumours | 223 | 91.5 | 3.1 | 1.6 | 1.9 | 2.6 | 2.3 | 1.8 | 2.1 | |
|  |  | Desmoplastic infantile astrocytoma | 21 | 100 | 2.1 | 0.1 | 0.1 | < 0.05 | 0.3 | 0.1 | 0.2 |
| Â | Â | Dysembryoplastic neuroepithelial tumour | 91 | 86.8 | 0.1 | 0.7 | 0.9 | 1.1 | 1.0 | 0.7 | 0.8 |
| Â | Â | Ganglioglioma | 96 | 93.8 | 0.6 | 0.7 | 0.8 | 1.3 | 0.9 | 0.9 | 0.9 |
|  |  | Central neurocytoma | 6 | 83.3 | 0.1 | 0.1 | < 0.05 | 0.1 | 0.1 | – | 0.1 |
|  |  | Papillary glioneuronal tumour | 3 | 100 | – | – | 0.1 | < 0.05 | < 0.05 | < 0.05 | < 0.05 |
|  |  | Gangliocytoma | 6 | 100 | 0.1 | 0.1 | 0.1 | < 0.05 | < 0.05 | 0.1 | 0.1 |
IIIe.5 | Meningioma | 50 | 88.0 | 0.1 | 0.3 | 0.3 | 0.8 | 0.4 | 0.5 | 0.4 | |
IIIf | Unspecified tumours | 196 | 19.9 | 4.5 | 1.6 | 1.5 | 1.9 | 2.0 | 1.8 | 1.9 | |
Xa | Germ cell tumours | 170 | 77.6 | 2.0 | 0.7 | 1.0 | 2.9 | 1.9 | 1.1 | 1.5 | |
|  |  | Germinoma | 119 | 76.5 | 0.1 | < 0.05 | 0.8 | 2.4 | 1.3 | 0.7 | 1.0 |
| Â | Â | Other | 51 | 80.4 | 1.8 | 0.7 | 0.1 | 0.4 | 0.6 | 0.4 | 0.5 |
| Â | Â | Total | 4166 | 78.8 | 40.7 | 44.4 | 38.6 | 37.0 | 42.6 | 37.5 | 40.1 |