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Fig. 2 | BMC Cancer

Fig. 2

From: Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

Fig. 2

Prevention of spontaneous rhabdomyosarcoma in BALB-p53Neu male mice by passive administration at the site of rhabdomyosarcoma onset of IGFs-neutralizing Monoclonal Antibodies (IGFs MAbs). IGFs MAbs consisted of a 1:1 mixture of KM3168 + KM1468 monoclonal antibodies. a Rhabdomyosarcoma tumor-free survival. b Salivary carcinoma-free survival. c Overall survival (as defined in Materials and Methods). Symbols and number of mice per group: open circles: controls (vehicle alone), n = 7; triangles: IGFs MAbs 0.2 + 0.2 μg/g, n = 9; diamonds: IGFs MAbs (1.0 + 1.0 μg/g), n = 5. Statistical significance by the Mantel-Haenszel test versus untreated controls is reported inside each panel

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