Fig. 1
From: Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis
IGF1R dependence of murine rhabdomyosarcoma RMSp53Neu-5 cell line. Soft agar growth is inhibited by IGF1R-neutralizing approaches. a Effect on agar growth of two different siRNAs against IGF1R (R1 and R4). Control bar refers to cells cultured in the presence of control siRNA not homologous to any mouse mRNA. Percentage of growth relative to oligofectamine only is shown. Star: significantly different from control siRNA (p < 0.05 at Student’s t test). b Dose-related growth inhibition in the presence of the IGF1R inhibitor NVP-AEW541. Dose “0” corresponds to controls containing vehicle alone