Fig. 2

The relationships of stem cell-related signatures. a Hierarchical clustering of expression signature from multiple stem cell-related signatures and those of tumor-infiltrating immune and stromal cells segregated into two major clusters. The CD133 down [gastric cancer (GC) and glioblastoma multiforme (GBM)] clusters included stromal and immune signatures (left). CD133-up (GC and GBM) clusters included embryonic stem cell signatures (ESC1 and ESC2) and those representing cell proliferation and the cell cycle (right). A heat map shows the level of the Pearson’s correlation coefficient (red and green for higher and lower correlations, respectively) in a pairwise manner. b–f As noted, scatter plots show the distribution of TCGA GC samples according to the expression levels from stem cell-related signatures