Fig. 1

The CD133-associated expression signature of gastric cancer (GC) cell lines. a Hierarchical clustering of 1000 highly variable genes segregated in three GC cell lines (SNU216, KATO-III and SNU601). Red and blue dots represent CD133+ and CD133- cells, respectively. b The commonly over- and under-expressed genes in CD133+ as CD133 signatures segregated in the CD133+ and CD133- cells regardless of cell line. c A functional association map linked the Gene Ontology terms according to their significant overlap of gene members. Network topology demonstrated two main subnetworks representing the cell cycle-, cytoskeleton-, and transporter-related molecular functions enriched in CD133+ and CD133- GC cell lines, respectively. The node size corresponds to the number of genes in the function