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Table 1 Baseline characteristic of studies included in the systematic review and meta-analysis

From: The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis

Author Publication year Country Study design Disease stage Percentage of adenocarcinoma (%) Sample size Mean age (years) Percentage male (%) Percentage of smoker (%) Percentage of TKI (%) NOS score
Hsiao [14] 2013 China Retrospective I–IV 100.0 139 NA 41.0 30.0 32.0 7
Han [20] 2016 China Retrospective I–IV 100.0 234 NA 53.4 44.0 30.3 8
Russo [21] 2017 Italy Retrospective IIIb-IV 73.0 137 66.2 59.1 77.4 NA 6
Baek [15] 2016 Korea Retrospective IV 70.0 259 68.0 64.5 59.1 NA 7
Stanic [22] 2014 Slovenia Retrospective I–IV 100.0 629 64.0 51.8 72.0 NA 8
Hsu [16] 2016 Canada Retrospective IV NA 543 66.0 40.0 NA 41.0 7
Hendriks [23] 2014 The Netherlands Retrospective NA 91.9 124 61.9 41.9 72.6 37.1 8
Iuchi [17] 2014 Japan Retrospective Ia-IV 79.4 1127 67.0 65.2 64.2 42.3 5
Arrieta [30] 2009 Mexico Prospective IIIb-IV 64.8 293 60.7 56.0 53.9 12.6 6
Lee [24] 2012 China Retrospective I-III 93.0 43 59.0 53.0 37.0 44.0 5
Iuchi [18] 2013 Japan Prospective NA 100.0 41 NA 29.3 21.9 NA 5
Li [25] 2015 China Retrospective NA 83.8 136 NA 52.9 58.8 30.9 7
Luo [31] 2013 China Retrospective I-IV 82.4 136 55.0 61.0 37.5 5.1 6
Zhuang [26] 2013 China Prospective I-IV 100.0 54 61.7 42.6 NA 42.6 7
Tomasini [27] 2016 France Retrospective IV 89.4 142 62.0 66.2 76.1 NA 6
Eichler [19] 2010 US Retrospective I-IV 94.0 93 60.9 33.0 57.0 19.0 8
Mak [28] 2015 US Retrospective NA NA 172 60.0 45.0 70.0 42.0 6
Wang [29] 2015 US Retrospective I-III 85.9 71 61.9 50.7 NA 21.1 5