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Table 2 Correlations between the LGR5 transcripts mRNA levels and the mRNA levels of different biomarkers

From: Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients

 

LGR5FL/RPII

LGR5Δ5/RPII

LGR5Δ8/RPII

LGR5all/RPII

EMTmarkers

 TWIST1

rs

0.379

0.258

0.177

0.350

p-value

0.001*

0.031

0.143

0.003

n

70

70

70

70

 SNAI1

rs

0.320

0.330

0.228

0.158

p-value

0.007

0.005

0.057

0.191

n

70

70

70

70

 ZEB2

rs

0.450

0.456

0.270

0.312

p-value

< 0.0001*

< 0.0001*

0.018

0.006

n

76

76

76

76

 MMP7

rs

0.373

0.288

0.308

0.363

p-value

0.001*

0.016

0.01

0.002*

n

70

70

70

70

 TCF7

rs

0.581

0.490

0.337

0.553

p-value

< 0.0001*

< 0.0001*

0.004

< 0.0001*

n

70

70

70

70

 Vimentin

rs

0.594

0.624

0.454

0.402

p-value

< 0.0001*

< 0.0001*

< 0.0001*

0.001*

n

70

70

70

70

 TGFβ

rs

0.402

0.305

0.285

0.261

p-value

< 0.0001*

0.007

0.013

0,023

n

76

76

76

76

Stem cell markers

NANOG

rs

0.187

0.137

0.219

0.383

p-value

0.121

0.259

0.068

0.001*

n

70

70

70

70

Oct3/4

rs

0.251

0.216

0.377

0.207

p-value

0.036

0.073

0.001*

0.086

n

70

70

70

70

Proteins involved in the metastatic process

 P4HA1

rs

0.390

0.236

0.276

0.167

p-value

< 0.0001*

0.037

0.014

0.144

n

78

78

78

78

 CTGF

rs

0.492

0.469

0.302

0.301

p-value

< 0.0001*

< 0.0001*

0.012

0.013

n

68

68

68

68

 IGF2

rs

0.498

0.485

0.316

0.271

p-value

< 0.0001*

< 0.0001*

0.009

0.025

n

68

68

68

68

 OPN

rs

0.281

0.240

0.301

0.079

p-value

0.020

0.049

0.013

0.522

n

68

68

68

68

Wnt signaling modulating genes

 RNF43

rs

−0.129

−0.171

−0.204

−0.123

p-value

0.287

0.158

0.090

0.311

n

70

70

70

70

 RSPO1

rs

0.097

0.131

0.040

0.051

p-value

0.427

0.284

0.743

0.678

n

69

69

69

69

  1. Bivariable Spearman’s Rho test. rs: correlation coefficient. The underlined genes have been shown to be Wnt- target genes. P-values were adjusted by the Bonferroni correction.* p-value ≤0.003 indicates statistical significance