Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice

Table 1 Number of regulated genes in skin of mice 2 weeks after administration of CTX with or without M30

Condition	Fold-change	P value	Mice (n)	Regulated genes (no.)
Condition	Fold-change	P value	Mice (n)	Total	Up	Down
CTX/Normal	> 1.5	< 0.05	Normal^a (3), CTX^b (3)	7722	3422	4300
MC/Normal	> 1.5	< 0.05	Normal (3), MC^c (3)	1148	866	282
MC/CTX	> 1.5	< 0.05	CTX (3), MC (3)	2753	1715	1038
Condition 1	> 1.5 (CTX/Normal) & < 0.666 (MC/CTX)	< 0.05	Normal (3), CTX (3), MC (3)	644
Condition 2	< 0.666 (CTX/Normal) & > 1.5 (MC/CTX)	< 0.05	Normal (3), CTX (3), MC (3)	241

^aNormal is normal mice: ^bCTX is cyclophosphamide-treated mice: ^cMC is M30-supplemented cyclophosphamide-treated mice

ISSN: 1471-2407