Skip to main content


Fig. 2 | BMC Cancer

Fig. 2

From: Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer

Fig. 2

Distribution of TILs and TIL subtypes through the whole tumor. These radar plots show the number of breast carcinomas being infiltrated by the different TIL infiltration categories. TIL-poor tumors were defined as BCs with low level infiltration or complete lack of TILs both at the ITF and in the TC. TIL-rich tumors had a moderate or high level of immune cell infiltration at both intratumoral areas. a High levels of total TILs were mainly observed at the ITF, whereas the TC contained generally less immune cells. The ITF was most frequently interspearsed with CD3+ T lymphocytes, CD20+ B cells and CD8+ T cells. CD68+ macrophages and and CD4+ T cells cells were found in lower amounts at the ITF. b In the TC, CD3+ T cells were found to be the prevalent subtype, whereas low amounts of CD20+, CD68+, CD4+ and CD8+ cells were present, or there was no immune infiltration in the TC at all. The TIL infiltration is depicted by the number of tumors showing the certain infiltration densities

Back to article page