Table 1 List of genes for gene express ion analysis. The short name and full name of the genes as well as their function are listed [40]
Gene | Official Full Name | Function (40) |
|---|---|---|
BAP1 | BRCA1 Associated Protein 1 | Promotes DSB repair |
BRCA1 | Breast Cancer 1 | Cell cycle checkpoints activation, resection of 5′ ends of the DSB, necessary for RAD51 function |
BRCA2 | Breast Cancer 2 | Localizes RAD51 to the DSB |
PARP1 | Poly (ADP-Ribose) Polymerase 1 | Initiates SSB repair |
RAD51 | RAD51 Recombinase | RAD 51 activity allows DNA to invade homologous double helix serving as template |
RAD50 | RAD50 double strand break repair protein | Forming of the MRN complex |
ATM | ATM serine/threonine kinase | Detection of DSB |
ATR | ATR serine/threonine kinase | Detection of DSB |
PALB2 | Partner and localizer of BRCA2 | Localizes BRCA2 to the DSB |
BARD1 | BRCA1 associated RING domain 1 | Binding partner of BAP1 |
EMSY | BRCA2 interacting transcriptional repressor | Transcription regulator that interacts with BRCA2 |
DDB2 | Damage specific DNA binding protein 2 | Required for DNA binding in DNA damage repair |
BACH1 | BTB domain and CNC homolog 1 | Transcriptional regulator that acts as repressor or activator |
MRE11 | MRE11 homolog, double strand break repair nuclease | Forming of the MRN complex |
NBN | nibrin | Forming of the MRN complex |
AURKA | Aurora kinase A | Kinase in cell-cycle, is involved in microtubule formation and stabilization at spindle pole during chromosome segregation |
FANCD2 | Fanconi anaemia complementation group D2 | Involved in HRR, is monoubiquinated in response to DNA damage |
BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | Involved in HHR by interaction with BRCA1 |
CHEK2 | Checkpoint kinase 2 | Cell cycle checkpoint regulator and putative tumour suppressor |
RPA1 | Replication protein A1 | Activates ATR |
GUSB | Glucuronidase beta | Normalization for digital expression analysis |
POLR1B | RNA polymerase I subunit B | Normalization for digital expression analysis |
TUBB | Tubulin beta class I | Normalization for digital expression analysis |
PGK1 | Phosphoglycerate kinase 1 | Normalization for digital expression analysis |