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Table 1 List of genes for gene express ion analysis. The short name and full name of the genes as well as their function are listed [40]

From: Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Gene Official Full Name Function (40)
BAP1 BRCA1 Associated Protein 1 Promotes DSB repair
BRCA1 Breast Cancer 1 Cell cycle checkpoints activation, resection of 5′ ends of the DSB, necessary for RAD51 function
BRCA2 Breast Cancer 2 Localizes RAD51 to the DSB
PARP1 Poly (ADP-Ribose) Polymerase 1 Initiates SSB repair
RAD51 RAD51 Recombinase RAD 51 activity allows DNA to invade homologous double helix serving as template
RAD50 RAD50 double strand break repair protein Forming of the MRN complex
ATM ATM serine/threonine kinase Detection of DSB
ATR ATR serine/threonine kinase Detection of DSB
PALB2 Partner and localizer of BRCA2 Localizes BRCA2 to the DSB
BARD1 BRCA1 associated RING domain 1 Binding partner of BAP1
EMSY BRCA2 interacting transcriptional repressor Transcription regulator that interacts with BRCA2
DDB2 Damage specific DNA binding protein 2 Required for DNA binding in DNA damage repair
BACH1 BTB domain and CNC homolog 1 Transcriptional regulator that acts as repressor or activator
MRE11 MRE11 homolog, double strand break repair nuclease Forming of the MRN complex
NBN nibrin Forming of the MRN complex
AURKA Aurora kinase A Kinase in cell-cycle, is involved in microtubule formation and stabilization at spindle pole during chromosome segregation
FANCD2 Fanconi anaemia complementation group D2 Involved in HRR, is monoubiquinated in response to DNA damage
BRIP1 BRCA1 interacting protein C-terminal helicase 1 Involved in HHR by interaction with BRCA1
CHEK2 Checkpoint kinase 2 Cell cycle checkpoint regulator and putative tumour suppressor
RPA1 Replication protein A1 Activates ATR
GUSB Glucuronidase beta Normalization for digital expression analysis
POLR1B RNA polymerase I subunit B Normalization for digital expression analysis
TUBB Tubulin beta class I Normalization for digital expression analysis
PGK1 Phosphoglycerate kinase 1 Normalization for digital expression analysis
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