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Fig. 2 | BMC Cancer

Fig. 2

From: Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Fig. 2

Senescence and apoptosis rate of cell lines after 48 h of incubation. a: The effect of both senescence and apoptosis is comparative in MRC-5. b: In MSTO-211H, the sharp increase of apoptotic effect of 181% of pemetrexed alone and in combination with cisplatin is illustrated, while senescence showed an effect of 100%. The well treated with 10 μM olaparib showed a senescence effect of 80%, while no apoptotic effect was detected. c: NCI H2052 cells showed apoptotic effects only in wells treated with cisplatin or in combination with pemetrexed or olaparib and senescence of 30–50%. Wells treated with 1 μM and 10 μM olaparib showed 40% of senescence, while no apoptotic effect was detected. d: NCI H2452 cells showed 70% of apoptosis and only 20% of senescence in wells treated with 0.5 μM, 1 μM or 10 μM olaparib combined with cisplatin. 10 μM Olaparib alone showed 15% higher senescence than apoptosis

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