Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Fig. 1

Enhanced base excision repair, due to defective HRR that is caused by BRCAness phenotype, increases the reliance on PARP1. It is suggested that loss-of-function mutation of BAP1 also results in BRCAness phenotype. Inhibition of PARP1 prevents the alternative repair pathway and thus could lead to apoptosis of the cell

Back to article page