Fig. 1From: Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitroEnhanced base excision repair, due to defective HRR that is caused by BRCAness phenotype, increases the reliance on PARP1. It is suggested that loss-of-function mutation of BAP1 also results in BRCAness phenotype. Inhibition of PARP1 prevents the alternative repair pathway and thus could lead to apoptosis of the cellBack to article page