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Table 2 Pathogenic mutation characteristics

From: Prevalence of germline mutations in the TP53 gene in patients with early-onset breast cancer in the Mexican population

  Exon Nucleotide Amino acid Type of Mutation Reported previously Classification Population
1 8 c.844C > T p.R282W missense yes pathogenic Puebla
2 5 c.517G > A p.V173 M missense yes pathogenic Oaxaca
3 6 c.604C > T p.R202C missense yes pathogenic Morelos
4 4 c.291delC p.P98Lfs*25 frameshift no pathogenic San Luis Potosí
5 4 c.273dupG p.P92Afs*57 frameshift no pathogenic Morelos