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Table 3 Comparison of performance efficiency between miRNA detection and Pap test for identifying missed high-grade lesions from colposcopy guided biopsy diagnosed LSIL/CIN1

From: MiRNA detection in cervical exfoliated cells for missed high-grade lesions in women with LSIL/CIN1 diagnosis after colposcopy-guided biopsy

miRNA AUC (95% CI) Sensitivity Specificity Positive predictive value Negative predictive value
95% CI P 95% CI P 95% CI P 95% CI P
miRNA195 0.86 (0.79–0.93) 88.9(69.7–97.0) < 0.001 78(70.3–80.1) 0.0013 42.1(29.4–55.8) 0.41 97.5(92.3–99.3) 0.0015
miRNA29a 0.89 (0.84–0.93) 92.6(74.2–98.7) < 0.001 80.7(73.2–86.4) 0.0077 46.2(32.8–60.2) 0.26 98.3(93.6–99.7) 0.00040
miRNA16–2 0.74 (0.65–0.83) 81.5(61.2–92.9) < 0.001 61.3(53.0–69.0) < 0.001 27.5(18.3–38.8) 0.71 94.8(87.8–98.0) 0.037
miRNA20a 0.83 (0.74–0.91) 77.8(57.2–90.6) < 0.001 80.7(73.2–86.4) 0.0077 42(28.4–56.7) 0.42 95.2(89.5–98.0) 0.014
pap test 0.56(0.44–0.69) 22.22(9.3–42.7)   91.3(85.3–95.1)   31.5(13.5–56.5)   86.7(80.1–90.3)  
  1. P value refers to the comparison between miRNA and Pap test with Pearson Chi-square test. All statistical tests were two-sided. P value in boldface is less than 0.05 and considered statistically significant
  2. The 95% confidence interval (CI) of proportions was calculated according to the following equation: p ±\( \sqrt{1.96\mathrm{p}\left(1-p\right)/n} \), where n is the case number involved in the calculation of the proportion
  3. AUC Area under curve
  4. CI Confidence interval